中等强度体力活动对康复期乳腺癌患者癌因性疲乏的干预效果

Effect of moderate physical activity on cancer related fatigue among breast cancer patients in recovery stage

目的探讨中等强度体力活动对康复期乳腺癌患者癌因性疲乏（CRF）的干预效果。方法将61例康复期乳腺癌患者采用抽签法随机抽样分为对照组30例与试验组31例。2组均予常规护理与运动处方干预，对照组根据自己身体情况进行适当运动锻炼，对运动强度无要求。试验组参照《2008美国体力活动指南》给予每天30 min的快步走运动处方干预。运动强度达到美国癌症协会（ACS）指南要求的中等体力活动水平。比较2组患者化疗前（T0期）、化疗结束后1周（T1期）、化疗结束后1个月（T2期）的疲乏指数、体力活动水平，分析两者之间的关系。结果疲乏指数方面，T0期2组差异无统计学意义（t=0.967，P〉0.05）；T1期、T2期试验组为（6.31 ± 0.81）、（4.71 ± 0.94）分，明显低于对照组的（6.92 ± 0.79）、（5.36 ± 0.91）分，差异有统计学意义（t=2.987、2.730，均P〈0.01）。体力活动水平方面，T0期2组差异无统计学意义（t=1.902，P〉0.05）；T1期、T2期试验组为（716.94 ± 71.09）、（828.87 ± 118.50）MET-minutes/week，明显高于对照组的（562.00 ± 94.47）、（718.47 ± 61.13）MET-minutes/week，差异有统计学意义（t=7.235、4.548，均P〈0.01）；采用Logistic回归分别分析了T1期、T2期的疲劳指数与年龄、体力活动水平、癌症分期、手术方式的相关性，疲乏指数与体力活动水平有显著相关性（P〈0.05），与年龄、癌症分期、手术方式无相关性（P〉0.05）。结论中等强度的体力活动水平可有效缓解康复期乳腺癌患者的CRF，有助于提升患者的生命质量。

Objective To explore the effectiveness of moderate intensity physical activity on cancer-related fatigue （CRF） in breast cancer patients during the convalescence in China.Methods A total of 61 participants were randomly assigned to two groups：30 cases in the control group, 31 cases in the experimental group. The two groups were given routine care and exercise prescription. The cases in the control group were informed of doing exercises according to physical condition. The experimental group did exercise by exercise prescription of 30-minute walk every day which met the American Cancer Society （ACS） guidelines for moderate physical activity. The patients fatigue index and physical activity were compared, simultaneously the relationship between the two groups in the pre-cheo phase （T0）, 1 week, after the end of chemotherapy （T1）, and 1 month after chemotherapy （T2） was analyzed.Results In terms of the fatigue index, there was no statistical difference between the two groups during the T0 period （t= 0.967, P 〉 0.05）. The experimental group at T1 and T2 were 6.31±0.81,4.71±0.94, significantly lower than those of the control group 6.92±0.79, 5.36±0.91, with a statistical difference （t= 2.987, 2.730, P 〈 0.01）. In terms of physical activity level, there was no statistical difference between the two groups during the T0 period （t= 1.902, P 〉 0.05）. The experimental group at T1 and T2 was （716.94±71.09）, （828.87±118.50） MET-minutes/week, significantly higher than the control group （562.00±94.47）,（718.47±61.13） MET-minutes/week, with a statistical difference （t= 7.235, 4.548, P 〈 0.01）. Using Logistic regression, the correlation between fatigue index and age, physical activity level, cancer staging, and surgical method was analyzed. There was a significant correlation between physical activity level and fatigue index （P 〈 0.05）. There was no correlation between fatigue index and age, stage of cancer, and surgical methods （P 〉 0.05）.Conclusions Moderate levels of physical activity can help improve the quality of life by means of significantly reduce CRF in patients with breast cancer during the convalescence.