全身麻醉对单纯鼾症患者术后认知功能的影响

The effect of general anesthesia on postoperative cognitive function in patients with simple snoring

目的通过评估单纯鼾症患者全身麻醉(全麻)手术前后血清S100β蛋白、血清神经元特异性烯醇化酶(NSE)的相关性,探讨全麻对该类患者手术前后认知功能的影响。方法择期全麻关节镜检查术,单纯鼾症(AHI<5)及睡眠正常患者各30例,术前、术后通过蒙特利尔认知功能量表(Montreal cognitive assessment,Mo CA)评估认知功能,分析两组血清S100β、NSE的变化趋势。结果与术前比,两组血清S100β及NSE在术毕及术后6 h、12 h升高(P<0.05)。与正常组比,鼾症组Mo CA评分差异无统计学意义(P>0.05),但血清S100β在术前、术毕、术后6 h有差异,NSE在术毕及术后6 h、12 h升高(P<0.05)。结论单纯鼾症患者全麻术后出现认知功能受损,但认知功能受损程度仅在血清学指标上有所改变。

Objective To assess the correlation between serum S100β protein and serum neuron-specific enolase（ NSE）levels before and after general anesthesia in patients with simple snoring（ SS） and investigate the effect of general anesthesia on the cognitive function of these patients before and after an operation. Methods Patients undergoing selective arthroscopy surgery under general anesthesia were divided into the SS（ AHI 5,n1 = 30） and normal sleep（ n2 = 30）groups. Pre-and post-operatively,the cognitive function was evaluated using the Montreal Cognitive Assessment（ Mo CA） test and the changes in serum S100β and NSE levels were analyzed in the two groups. Results Compared to the preoperative levels,serum S100β and NSE levels in both groups significantly increased at the end of and 6 h and 12 h after surgery（ P〈0.05）. Compared to that of the normal sleep group,there was no significant difference in the Mo CA scores in the SS group（ P〉0.05）. However,levels of serum S100β were different preoperatively and at the end of and6 h after surgery（ P〉0.05）. NSE levels increased at the end of and 6 h and 12 h after surgery（ P〉0.05）. Conclusion Patients with simple snoring after general anesthesia had impaired cognitive function,but the extent of cognitive impairment was was only reflected by serological changes.