2,2-二甲基-4-环己烯-1,3-二酮的合成

Synthesis of 2,2-Dimethyl-4-Cyclohexene-1,3-Dione

美丽红豆杉素B(Taxamairin B,I)是从美丽红豆杉茎皮中分离获得的化学成分之一,对肝癌细胞有一定的抑制作用。我们曾报道了(C环部分的中间体3-异丙基-4,5-二甲氧基苯乙酮缩酮的合成。2,2-二甲基-4-环己烯-1,3-二酮(Ⅱ)是全合成美丽红豆杉素B的中间体之一。Hart在研究6,6-二甲基-4。

2,2-Dimethyl-4-cyclohexene-1, 3-dione (Ⅲ) is an important intermediate for the total synthesis of Taxamairin B. A new synthetic route was designed. The compound Ⅲ was obtained by methylation, bromination and dehydrobromination of 2-methyl-1,3-cyclohexanedione (Ⅳ), which was prepared from adipic acid.