相关生化检测在脑出血患者急性期的临床意义

Application of blood lipid,uric acid and glucose in patients with acute cerebral hemorrhage and its prognostic value

目的探讨血脂、尿酸、血糖检测对于脑出血急性期患者的应用及预后预测价值。方法选择2014年4月~2016年6月由我院接诊的120例急性脑出血患者,根据预后状况良好和无效分为预后良好组和预后不良组,各60例,另选我院60名健康职工为常规组。检测所有参与者血总胆固醇、三酰甘油、高密度蛋白胆固醇(HDL-C)、低密度蛋白胆固醇(LDL-C)、尿酸及血糖指标并进行比较;另外将上诉6项指标加上年龄作为自变量,将患者预后情况作为因变量,通过二分类Logistical建立回归方程。结果 3组血总胆固醇和三酰甘油比较差异无统计学意义(P>0.05),预后良好组HDL-C低于预后不良组,LDL-C高于预后不良组,差异具有统计学意义(P<0.05)。3组尿酸及血糖均有统计学意义,其中常规组两项指标均最低,预后不良组均最高(P<0.05)。HDL-C、尿酸、血糖及年龄是急性脑出血不良预后的危险因素。结论血脂、尿酸、血糖的检测对于脑出血急性期患者的诊治具有指导意义,且安全性高,值得推广。

Objective To study the application of blood lipid, uric acid and glucose in patients with acute cerebral hemorrhage and its prognostic value. Methods 120 patients of acute cerebral hemorrhage received therapy from April 2014 to June 2016 in our hospital,according to the good and invalid prognosis, were divided into Good prognosis group and Poor prognosis group. 60 healthy workers in our hospital were selected as routine group. Plasma total cholesterol, triglyceride, high density lipoprotein cholesterol（HDL-C）, low density lipoprotein cholesterol（LDL-C）, uric acid, and blood glucose were measured. Results There were no significant differences in serum total cholesterol and triglyceride a- mong the three groups（P〉0.05）. HDL-C in Good prognosis group was lower than that in Poor prognosis group（[1.35 ±0.42]mmol/L vs[1.49 ±0.41]mmol/L）. LDL-C in Good prognosis group was higher than that in Poor prognosis group （[2.71±0.83]mmol/L vs[2.68 ± 0. 75]mmol/L） （P〈 0.05）. The uric acid and blood glucose of three groups were statistically significantly different. The uric acid and blood glucose of conventional group were the highest and those o Poor prognosis group were lowest among the three groups（P^0.05）. HDL-C, uric acid, blood glucose and age were the risk factors of poor prognosis of acute cerebral hemorrhage. Conclusion Blood lipids, uric acid and blood glucose tes ting for the diagnosis and treatment of patients with acute cerebral hemorrhage have a guiding significance and safe.