维生素D对急性腹泻患儿血清25(OH)D与炎症因子水平的影响

Effect of vitamin D on serum level of 25 (OH) D and inflammatory factors in children with acute diarrhea

目的探讨维生素D对急性腹泻患儿血清25-羟维生素D[25(OH)D]与炎症因子水平的影响。方法选取急性腹泻患儿100例,依据治疗方法分为观察组和对照组,每组50例,对照组给予蒙脱石散散剂+枯草杆菌二联活菌颗粒口服治疗,观察组在此基础上联合维生素D治疗,观察比较两组治疗效果及两组患儿血清25(OH)D、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平。结果观察组治疗后血清25(OH)D水平明显高于对照组,血清IL-6、TNF-α水平明显低于对照组,差异均有统计学意义(t分别=11.81、7.54、7.96,P均<0.05);观察组呕吐、大便次数和性状复常时间明显少于对照组,差异有统计学意义(t分别=8.45、6.85、4.68,P均<0.05);观察组治疗有效率明显高于对照组,差异有统计学意义(χ~2=6.06,P<0.05);观察组和对照组其他症状发生率基本相同,差异无统计学意义(χ~2=0.38,P>0.05)。结论补充维生素D治疗可有效提高急性腹泻患儿的治疗疗效,其可能与改善机体25(OH)D水平和炎症状态有关,且具有良好的安全性。

Objective To investigate the effect of vitamin D on serum levels of 25（OH）D and inflammatory factors in children with acute diarrhea. Methods Totally 100 cases of children with acute diarrhea were selected and divided into the control group and the observation group according to the different therapies with 50 cases in each.The control group was given regimen consisting of montmorillonite and live binary bacillus subtilis,the observation group was given vitamin D based on the treatment of control group. The curative effect and the levels of serum 25（OH）D,IL-6,TNF-α levels were observed and compared. Results The level of serum 25（OH） D of the observation group after treatment was significantly higher than that of the control group,the serum IL-6 and TNF-α levels were significantly lower than those of the control group（t =11.81,7.54,7.96,P 〈0.05）. The vomiting,stool frequency and characters of recovery time of observation group were better than those of control group（t=8.45,6.85,4.68,P〈0.05）.The effective rate of the observation group was significantly higher than the control group（χ2=6.06,P 〈0.05）. The incidence of other symptoms between the control group and the observation group was not statistically different（χ2=0.38,P〉0.05）. Conclusion Vitamin D supplementation can effectively improve the therapeutic efficacy in children with acute diarrhea. It may be related to the improvement of the level of 25（OH）D and the inflammatory state of the body.