瓜蒌薤白半夏汤治疗慢性肺源性心脏病急性发作期患者临床疗效观察

Effect of Gualou Xiebai Banxia Decoction on chronic pulmonary heart disease in patients with acute exacerbation

目的探讨瓜蒌薤白半夏汤治疗慢性肺源性心脏病急性发作期患者临床疗效观察。方法选择慢性肺源性心脏病急性发作期患者93例,按照随机数字表法分为观察组47例和对照组46例。对照组患者采用常规西医治疗,观察组在对照组基础上结合瓜蒌薤白半夏汤治疗。两组患者治疗疗程均为2周。比较两组患者治疗疗效,治疗前后肺功能指标呼气流量峰值(PEF)、1 s用力呼气量(FEV1)和用力肺活量(FVC)及血浆粘度、纤维蛋白原和内皮素-1(ET-1)变化。结果观察组的治疗总有效率高于对照组,差异均有统计学意义(χ2=6.07,P<0.05)。两组患者治疗后PEF、FEV1和FVC均高于治疗前,血浆粘度、纤维蛋白原和ET-1低于治疗前,差异均有统计学意义(t分别=15.18、9.61、12.87、9.30、4.68、6.82、16.55、27.69、32.62、7.23、12.04、20.79,P均<0.05);观察组患者治疗后PEF、FEV1和FVC高于对照组治疗后,血浆粘度、纤维蛋白原和ET-1低于对照组治疗后,差异均有统计学意义(t分别=8.18、5.00、6.44、11.38、15.86、13.88,P均<0.05)。结论瓜蒌薤白半夏汤治疗慢性肺源性心脏病急性发作期患者临床疗效明显,且可改善患者肺功能、血液流变学及血管内皮功能。

Objective To investigate the effect of Gualou Xiebai Banxia decoction on chronic pulmonary heart disease in patients with acute exacerbation. Methods Totally 93 patients with acute exacerbation of chronic pulmonary heart disease were divided into the observation group with 47 cases and the control group with 46 cases according to the random number table method. The control group was treated with conventional western medicine treatment,the observation group was treated with Gualou Xiebai Banxia decoction on the basis of the conventional treatment. The course of treatment was 2 weeks in the two groups. The curative effect,lung function parameters including peak expiratory flow（PEF）,one second forced expiratory volume（FEV1）and forced vital capacity（FVC）before and after treatment,plasma viscosity,fibrinogen and endothelin-1（ET-1）levels between the two groups were compared.Results The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant（χ~2=6.07,P〈0.05）. The PEF,FEV1,and FVC after treatment of two groups were significantly higher than those before treatment,while the plasma viscosity,fibrinogen,and ET-1 were significantly lower than those before treatment（t=15.18,9.61,12.87,9.30,4.68,6.82,16.55,27.69,32.62,7.23,12.04,20.79,P〈0.05）. Patients in the observation group after treatment had higher levels of PEF,FEV1,and FVC compared to the control group after treatment,while the plasma viscosity,fibrinogen,and ET-1 were significantly lower than the control group after treatment（t=8.18,5.00,6.44,11.38,15.86,13.88,P 〈0.05）. Conclusion Gualou Xiebai Banxia decoction has obvious effect on chronic pulmonary heart disease in patients with acute exacerbation,it can improve lung function,hemorheology and vascular endothelial function.