牙周组织工程与再生

Periodontal tissue engineering and regeneration

牙周病的临床治疗是国际关注的难题,牙周缺损组织的修复面临严峻挑战.传统牙周治疗聚焦炎症控制,虽可阻止或延缓疾病进程,却难以获得牙周再生.从20世纪80年代末开始,引导组织再生（guided tissue regeneration,GTR）、引导骨再生（guided bone regeneration,GBR）等新技术的广泛开展和临床应用,大大提高了牙周病的治疗水平.进入21世纪,干细胞治疗和组织工程研究得到突飞猛进的发展.利用组织工程的原理、技术和方法,有望实现牙周组织的生理性和功能性再生.

The clinical management of periodontal disease is a global concern, and the regeneration of periodontal tissue defects due to periodontitis faces a huge challenge in the field of regenerative dentistry. Although conventional periodontal therapies focusing on in flammation control could stop or delay the progression of the disease, periodontal regeneration remains an elusive but laudable goal. Since late 1980s, concerted efforts have been made to accelerate and augment periodontal repair by using guided tissue regeneration （GTR）, guided bone regeneration （GBR） and a wide range of other regenerative paradigms. Those advances have largely improved the clinical outcomes of periodontal therapies. In the past several years of 21st century, many progresses were made in the developments of stem cell therapy and tissue engineering, including remarkable biological discoveries in the laboratory as well as great curative successes in preclinical scenarios. The use of the principles, techniques and procedures of tissue engineering in periodontology showed great potential to regenerate new functional periodontal tissues such as alveolar bone, periodontal ligament, root cementum and finally and predictably the normal structure and functionality of the periodontium around a previously diseased tooth.