某院新生儿败血症病原菌分布、耐药性及3年变迁情况调查分析

Investigation and Analysis of Pathogenic Bacteria Distribution, Drug Resistance and 3 Year Changes of Neonatal Septicemia in A Hospital

目的分析我院近3年间新生儿败血症病原菌分布及耐药性变迁情况。方法回顾性分析我院收治的114例新生儿败血症患儿临床资料。记录患儿病原菌分布情况及常见病原菌对常用抗生素的耐药性变化情况。结果 114例患儿共培养出病原菌株122株,其中G+菌占比最高,G^-其次,真菌占比最小。患儿G+菌及真菌占比逐年递增,G^-菌占比下降。我院新生儿败血症常见G+菌、G^-菌对常用抗生素的耐药性变化均未有统计学差异。结论我院近3年新生儿败血症病原菌分布及病原菌耐药情况均未见明显变化,建议医师根据患儿血培养及药敏检查结果选择最佳抗生素。

Objective To analyze the distribution and drug resistance of neonatal septicemia in our hospital during the past 3 years. Methods the clinical data of 114 neonates with septicemia in our hospital were analyzed retrospectively. The distribution of pathogens and drug resistance of common pathogens to antibiotics were recorded. Results 122 strains of pathogenic bacteria were isolated from 114 children, among them, G^＋ accounted for the highest proportion, followed by G-, fungi accounted for the smallest. The prop6rtion of G＋ bacteria and fungi increased year by year, and the proportion of G- bacteria decreased. In our hospital, there were no statistically significant differences in the resistance of common bacteria to G＋ and G- among neonates with septicemia. Conclusion In our hospital, the distribution of pathogenic bacteria and the resistance of pathogens have not changed significantly in recent 3 years. It is suggested that the best antibiotics should be selected according to the results of blood culture and drug sensitivity test.