冰毒使用者抑制控制的损伤、可逆性及干预策略

The injury,reversibility and intervention strategies of inhibitory control for methamphetamine users

冰毒使用的危害日益凸显,受到社会的普遍关注。行为、认知和脑功能的研究结果一致表明:长期的冰毒使用会导致使用者的抑制控制受损,包含一般抑制控制损伤以及药物相关线索条件下的损伤。这些损伤与前额脑区的异常密切相关,对冰毒使用者的行为和认知能力产生不良影响。目前,这些损伤只能部分恢复,因此,改善冰毒使用者抑制控制的干预策略成为热点。未来研究可以从不同药物成瘾者的差异性、多药物使用模式以及有区别的运动干预等方面对冰毒使用者的抑制控制损伤进行深入研究。

The dangers of methamphetamine use become increasingly prominent, and has received widely public attention. Numerous evidence from behavioral and neuroimaging studies has consistently shown that chronic methamphetamine consumption can cause a deficit of inhibitory function, particularly in the context of drug-related cues, deriving from dysfunction of the brain regions associated with inhibition, including prefrontal cortex etc. These pathological changes adversely affect cognitive performance and daily function. At present, It has been shown that inhibitory control dysfunction induced by methamphetamine use can be recovered to some degree following abstinence. Therefore, the intervention strategies that devote to improve the inhibitory control of methamphetamine users become very important. Future research in this field should address the specificity of inhibitory control associated with substance use, and consider the patterns of multiple drug abuse and the difference of exercise intervention strategies.