喜炎平注射液治疗小儿毛细支气管炎疗效及安全性的Meta分析

The Efficacy And Safety Of Xiyanping Injection in Treating bronchiolitis in infant: A Meta-analysis

目的评价喜炎平注射液治疗小儿毛细支气管炎的疗效及安全性。方法检索中国期刊全文数据库(CNKI)、中文期刊全文数据库(VIP)、中国生物医学文献数据库(CBM)、Pubmed和Web of Science等中英文数据库,根据纳入与排除标准纳入筛选文献;由两名评价员进行Jadad质量评分并提取相关数据进行Meta分析。结果纳入12个随机对照试验(RCT)共计1230个病例。喜炎平注射液的总有效率、退热时间、咳嗽消失时间、肺部啰音消失时间、住院治愈时间等结局指标更具有优势,两组临床疗效的差异有统计学意义,但两组在憋喘缓解时间方面差异无统计学意义。结论喜炎平注射液治疗小儿毛细支气管炎的疗效优于利巴韦林注射液。但由于纳入文献的研究质量不高,尚需开展更多高质量的随机对照试验来进一步评价。

Objective This study was to assess the efficacy and safety of Xiyanping Injection in curing bronchiolitis in infant.Methods Some Chinese-English databases including Web of Science,Pubmed,CBM,CNKI,VIP were searched to collect the Randomized controlled trials（RCTs）.After two reviewers have selected trials independently and assessed methodologically quality by Jadad scale,valid data would be extracted to make a Meta-analysis. Results A total of 12 RCTs were brought in including 1230 cases.Meta-analysis showed that,the treatment group of Xiyanping has advantages on the total effective rate,cooling time,cough-disappear time, rales disappeared time and the healing time. However,both of the groups didn＇t show significant difference on asthma-disappear time.Conclusion We concluded that the efficacy of treatment group which combine Xiyanping Injection is superior to Ribavirin injection.However,higher quality clinical studies are needed as most trials included in this review were of lower quality.