活血降糖饮治疗2型糖尿病气阴两虚证30例

On Treatment of 30 Cases of Type 2 Diabetes with Qi-Yin Deficiency Syndrome by Huoxue Jiangtang Potion

目的研究活血降糖饮对2型糖尿病气阴两虚患者的治疗作用以及对DPP-4活性的影响。方法我院门诊及住院2型糖尿病患者共60例分为治疗组和对照组各30例,均给予磷酸西格列订口服治疗,治疗组加用活血降糖饮。分别记录年龄、性别、糖尿病病程、治疗前后证候积分、空腹及餐后2小时血糖、空腹及餐后2小时胰岛素、空腹及餐后2小时DPP-4酶活性。结果经治疗两组患者证候积分、空腹及餐后2小时血糖、空腹及餐后2小时DPP-4活性均明显下降,空腹及餐后2小时胰岛素明显升高,差异均有统计学意义(P<0.05,P<0.01);经治疗治疗组证候积分、餐后2小时血糖、餐后2小时胰岛素、餐后2小时DPP-4活性均较对照组降低更加明显,差异有统计学意义(P<0.05,P<0.01);治疗组证候积分、餐后2小时血糖、餐后2小时胰岛素、餐后2小时DPP-4活性治疗前后差值均较对照组明显增加(P<0.05,P<0.01)。结论活血降糖饮可以改善气阴两虚2型糖尿病患者临床症状,降低空腹和餐后血糖,增加空腹和餐后胰岛素分泌,对于餐后血糖和胰岛素的改善作用较空腹更加明显,其作用可能与降低餐后DPP-4酶活性有关。

Objective：To investigate the therapeutical effect of Huoxue Jiangtang potion on patients of type 2 diabetes with qi-yin deficiency syndrome and its effect on DPP-4 activity.Methods：60 patients with type 2 diabetes from both the outpatient and inpatient departments were randomized into treatment group and control group with 30 case in each.Both groups were orally given sitagliptin phosphate and the cases of the treatment group were additionally given Huoxue Jiangtang potion.The patients＇ age,sex,course of the disease,syndrome integral before and after the treatment,fasting and 2h postprandial blood glucose,fasting and 2h postprandial plasma insulin,fasting and postprandial DPP-4 enzyme activity were recorded.Results：After the treatment,the syndrome integral,fasting and 2hpostprandial blood glucose as well as fasting and postprandial DPP-4 enzyme activity decreased significantly,while the fasting and 2h postprandial plasma insulin increased greatly,the differences had statistical significance（P〈0.05,P〈0.01）.The syndrome integral,2h postprandial blood glucose,2h postprandial plasma insulin and 2h postprandial DPP-4 enzyme activity of the treatment group decreased more significantly than those of the control group after the treatment,the differences were statistically significant（P〈0.05,P〈0.01）.The differences before and after the treatment in the syndrome integral,2h postprandial blood glucose,2h postprandial plasma insulin and 2h postprandial DPP-4 activity of the treatment group increased more significantly than those of the control group and had statistical significance（P〈0.05,P〈0.01）.Conclusion：Huoxue Jiangtang potion can improve the clinical symptoms of patients of type 2 diabetes with qi-yin deficiency,reduce fasting and postprandial blood glucose,increase fasting and postprandial insulin secretion.It is more effective in improving fasting blood glucose and insulin than in postprandial conditions and its effect may be related to reducing postprandial DPP-4 enzyme activity.