针灸调理冲任对输卵管炎性阻塞性不孕症临床研究

Clinical Study on Treatment of Infertility with Salpingitis Obstruction by Acupuncture and Moxibustion

目的:观察针灸调理冲任在治疗输卵管炎性阻塞性不孕症上的临床疗效。方法:将符合标准的120例输卵管炎性阻塞性不孕症患者随机分为观察组和对照组,每组各60例。观察组采取针灸调理冲任的方法,对照组采取常规针灸的方法。连续治疗3个月经周期为1个疗程,2组患者均连续治疗2个疗程。分别检测2组患者治疗前后白介素-6(IL-6)、肿瘤坏死因子-a(TNF-a)等理化指标变化情况,治疗1年内宫内妊娠及输卵管畅通情况;结果:(1)治疗后临床总疗效分析,观察组与对照组分别为83.33%和65.0%,差异显著(P<0.05);(2)治疗前后组内比较,2组血清IL-6、TNF-a水平差异均有统计学意义(P<0.05);治疗后组间比较,2种治疗方法对血清IL-6及TNF-a的降调差异无统计学意义(P>0.05);(3)自治疗起1年内,观察组、对照组宫内妊娠率分别58.33%、35.0%,差异有统计学意义(P<0.05);(4)即使未能成功受孕,经HSG检查发现观察组可获得更高的输卵管通畅率。结论:针灸调理冲任治疗输卵管阻塞性不孕症疗效满意,其机制可能与其降低血液及输卵管组织中炎性介质IL-6,TNF-a的表达,促进炎症吸收有关。

Objective： To observe the therapeutic effect of acupuncture and moxibustion on treating infertility caused by oviduct obstruction infertility. Methods： 120 cases of tubal obstructive infertility patients were randomly divided into observation group and control group, 60 cases in each group. The observation group took acupuncture regulating Chong and Ren, the control group received conventional acupuncture. Continuous treatment of 3 menstrual cycle for a course of treatment. Two groups of patients were treated continuously for 2 courses（6 menstrual cycles）. The levels of interleu- kin-6（IL-6） and tumor necrosis factor-α （TNF-α ） were measured before and after treatment in both groups. Treat- ment of intrauterine pregnancy in 1 years and the patency of fallopian tubes. Results： ① The clinical efficacy of the treatment was analyzed, the total effective rate of the observation group and the control group were 83.33% and 65.0%. The difference was significant（P〈0.05）. ② Compare before and after treatment within the group, The differences of se- rum IL-6 and TNF-α levels between the two groups were statistically significant（P〈0.05）, But the therapeutic effects were compared between the two groups. There was no significant difference in serum IL-6 and TNF-α between the two treatments（P〉0.05）. ③ Autonomous treatment within 1 years. The intrauterine pregnancy rates of the observation group and the control group were 58.33%, 35.0%. The difference was statistically significant （P〈0.05）. ④ Even if unsuccess- ful pregnancy, the observation group had higher patency rate（P〈0.05）. Conclusion： Acupuncture and moxibustion shows good effect in the treatment of tubal infertility. The mechanism may be related to its reduction of blood and fallopian tube tissue inflammatory mediators IL-6, TNF- α expression, promote inflammation absorption.