肤痔清软膏联合中药灌肠治疗盆腔炎合并痔疮临床观察

Clinical Observation of Fuzhi Qing Ointment Combine with Chinese Medicine Enema in Treating Pelvic Inflammation Accompany with Haemorrhoids

目的:探讨肤痔清软膏联合中药灌肠在治疗盆腔炎合并痔疮患者的临床价值。方法:选取90例慢性盆腔炎合并痔疮患者,按照随机数字表法随机分为抗生素+肤痔清组(KF)、抗生素+肤痔清+中药保留灌肠组(KFZ)和抗生素+润滑剂+中药保留灌肠组(KRZ)3组,每组30例。观察临床疗效、临床症状改善状况;观察炎症指标CRP、促炎因子TNF-α、抑炎因子IL-10在治疗前后的变化情况。结果:治疗后KFZ、KRZ有效率均为96.67%,明显高于KF有效率为76.67%,KFZ组、KRZ组优于KF组;治疗后3组患者TNF-α、IL-10、CRP均有改善,与KF组相比,KRZ组、KFZ组在降低炎症指标TNF-α、CRP,提高抑炎因子IL-10优于KF组(P<0.05);KRZ组与KFZ组比较,KFZ组在降低炎症指标CRP,提高抑炎因子IL-10方面优于KRZ组(P<0.05)。治疗后KRZ与KFZ组在下腹疼痛、腰骶疼痛、白带异常临床症状改善优于KF组(P<0.05);KFZ组在便血疼痛临床症状改善优于KF组(P<0.05)。结论:肤痔清软膏联合中药灌肠在治疗盆腔炎患者时具有协同作用,能够提高疗效,显著改善患者炎症状况,且对合并痔疮的盆腔炎患者在改善临床症状具有优势。

Objective： To explore the clinical value of Fuzhi Qing ointment combine with Chinese medicine enema in treating pelvic inflammation accompany with haemorrhoids. Methods： 90 patients with chronic pelvic inflammatory disease complicated with hemorrhoids were randomly divided into two groups： antibiotic＋skin hemorrhoids group （KF）, antibiotic＋skin hemorrhoids＋traditional Chinese medicine retention enema group （KFZ） and antibiotics＋lubricant＋tra ditional Chinese medicine Retention enema group （KRZ） 3 groups, 30 eases in each group. The changes of CRP, pro- inflammatory cytokines TNF- α and anti-inflammatory cytokines IL-10 were observed before and after treatment. The changes of CRP, pro-inflammatory cytokines TNF- α and anti-inflammatory cytokines IL-IO were observed before and after treatment. Results： After treatment, the effective rate of KFZ and KRZ was 96.67%, which was significantly higher than that of KF （76.67%）. KFZ group and KRZ group were better than KF group. After treatment, TNF-α, IL- 10 and CRP （P〈O.05）. Compared with the KF group, the KLZ group was significantly higher than that of the KF group （P〈O.05）. Compared with the KFZ group, the KFZ group was significantly higher than that in the KF group reduce the inflammatory index of CRP, improve the anti-inflammatory cytokines IL-10 is better than KRZ group （P〈0.05）. The clinical symptoms of KFZ group were better than those of KF group （P〈O.05）. The clinical symptoms of lower limb pain, lumbosacral pain and vaginal discharge were better than those of KF group （P〈O.05）. Conclusion： Fuzhi Qing ointment combined with traditional Chinese medicine enema in the treatment of patients with pelvic inflammatory disease has synergistic effect, can improve the efficacy, significantly improve the patient＇ s inflammatory condition, and patients with pelvic inflammatory hemorrhoids in patients with improved clinical symptoms have advantages.