电针灸对轻度OSAHS患者血清细胞因子浓度的影响及疗效观察

Efficacy of electroacupuncture for patients with mild obstructive sleep apnea hypopnea syndrome

目的探讨电针灸对轻度阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血清细胞因子浓度的影响及疗效。方法选取经多导睡眠监测诊断为轻度OSAHS患者80例,采用随机数字表法分为电针组和对照组各40例。两组患者研究期间均予实施传统的健康教育与注意事项告知,对照组患者进行中药施治,电针组加用电针灸治疗,疗程8周。比较两组患者治疗前后睡眠呼吸暂停低通气指数(AHI)、最长呼吸暂停时间、夜间最低血氧饱和度(SpO_2)水平及血清NF-κB、IL-6、TNF-α浓度等指标的变化。结果治疗8周后,电针组AHI、最长呼吸暂停时间均较治疗前减少,夜间最低SpO_2水平均较治疗前升高,血清NF-κB、IL-6和TNF-α浓度均较治疗前降低,差异均有统计学意义(均P<0.05),对照组AHI、最长呼吸暂停时间、夜间最低SpO_2水平、血清NF-κB、IL-6和TNF-α浓度均较治疗前无明显变化,差异均无统计学意义(均P>0.05)。治疗8周后,电针组AHI、最长呼吸暂停时间少于对照组,夜间最低SpO_2水平高于对照组,血清NF-κB、IL-6和TNF-α浓度均低于对照组,差异均有统计学意义(均P<0.05)。结论电针灸治疗轻度OSAHS取得良好效果,能有效降低血清NF-κB、IL-6和TNF-α浓度,减轻机体的炎症反应,改善临床症状。

Objective To assess the efficacy of electroacupuncture in treatment of patients with mild obstructive sleep apnea hypopnea syndrome（OSAHS）. Methods Eighty patients diagnosed as mild OSAHS by polysomnography were randomly divided into study group and control group with 40 cases in each group. Patients in both groups received health education and Chinese medical herbs for 8 weeks, while those in study group were given additional electroacupuncture. The sleep apnea hypopnea index（AHI）, the longest apnea time, the lowest nocturnal oxygen saturation（SpO2）, the serum nuclear factor-κB（NF-κB）, interleukin-6（IL-6） and tumor necrosis factor-α（TNF-α） levels were measured and compared before and after medical treatment in two groups. Results After 8 weeks of treatment, the AHI and the longest apnea time in study group were declined, the lowest nocturnal SpO2 improved, and the serum NF-κB, IL-6 and TNF-α levels were decreased significantly（all P0.05）, while there were no significant changes in above indicators in control group（all P〈0.05）. After treatment, the AHI, the longest apnea time, serum NF-κB, IL-6, TNF-α levels in study group were lower, the lowest nocturnal SpO2 was higher than those in the control group（all P〈0.05）. Conclusion Electroacupuncture can effectively alleviate symptoms of mild OSAHS patients, and attenuate the inflammatory reaction with decreased serum NF-κB, IL-6 and TNF-α levels.