溃疡性结肠炎合并贫血患者的临床特征

Clinical characteristics of anemia in ulcerative colitis

目的 探讨溃疡性结肠炎（UC）合并贫血患者的发病率及临床特征,分析贫血相关的影响因素.方法 回顾性分析200例UC患者的临床资料,统计UC合并贫血的发病率,分析病变部位、疾病活动度、实验室指标与贫血的关系.结果 200例UC患者中103例合并贫血（51.3％）,其中轻度贫血91例（88.3％）,中度贫血10例（9.7％）,重度贫血2例（2.0％）;小细胞低色素贫血25例（24.3％）,正常细胞性贫血77例（74.8％）,大细胞性贫血1例（0.9％）.轻、中、重度活动UC患者贫血发生率比较差异有统计学意义（P＜0.05）.不同性别及不同病变部位患者的贫血发生率比较差异均无统计学意义（P＞0.05）.贫血患者的RBC计数及Hb水平均低于非贫血患者,CRP及ESR水平均高于非贫血患者,差异均有统计学意义（P＜0.01）.Logistics回归分析结果显示,UC合并贫血与RBC计数呈正相关（OR=111.420,95％CI 21.126 ～451.661,P＜0.001）,而与CRP、ESR、疾病活动度等无相关性（P＞0.05）.结论 贫血在UC患者中较常见,UC合并贫血与RBC计数相关,而与机体炎症状态、疾病分型无关.

Objective To investigate the prevalence and clinical characteristics of anemia in ulcerative colitis （UC）,and analyse its factors related to anemia.Methods Clinical data of 200 patients with UC were retrospectively analyzed and the correlation between anemia and factors including of location,disease activity and biochemical indicators were assessed.Results The prevalence of anemia was 51.3% （103/200）.Among 103 cases,91 cases were mild anemia（88.3%）,10 cases were moderate anemia（9.7%） and 2 cases were severe anemia（2.0%）.A total of 25 cases were microcytic anemia （24.3%）,77 cases were normal cell anemia（74.8%） and 1 case was large cell anemia（0.9%）.The numbers of patients with light,moderate and severe disease activity were significantly different（P 〈 0.05）.There was no significant difference in sex and lesion location between UC patients with anemia and those without anemia（P 〉 0.05）.Comapred to patients without anemia,the levels of RBC and hemoglobin were lower,while C-reactive protein （CRP） and erythrocyte sedimentation rate （ESR） were higher,and the differences were statistically （P 〈 0.01）.Logistic regression showed that,anemia in UC was positively associated with RBC leve（OR =111.420,95% CI21.126-451.661,P 〈 0.001）,while had no association with CRP,ESR and disease activity（P 〉 0.05）.Conclusion Anemia is common in patients with UC.Anemia in UC is related to the level of RBC,but has no correlation with inflammation state and disease activity.