兰州地区极早产儿相关危险因素的出生队列研究

A birth cohort study on related risk factors of very preterm infants in Lanzhou

目的探讨我院极早产儿相关危险因素。方法回顾性调查2010年1月至2012年12月在我院住院分娩的极早产儿的住院资料及母亲相关因素。并以同期足月儿作为对照。结果共有98例极早产儿纳入本研究,非条件Logistic回归分析发现,多胎妊娠(OR=13.592,95%CI:7.015-26.333)、母亲妊高征(OR=4.15,95%CI:2.339-7.363)、母亲妊娠年龄<25岁(OR=2.072,95%CI:1.224-3.507)、母亲孕期吸烟(OR=1.796,95%CI:1.162-2.776)均为极早产发生的高危因素,而产妇文化程度较高则为极早产的保护因素(OR=0.384,95%CI:0.203-0.725)。结论尽早发现极早产儿的发生的高危因素,能更好的在产检阶段做好宣教,从而降低极早产的发生率。

Objective：To investigate the related risk factors of very preterm infants in our hospital. Methods：A retrospective birth cohort study was conducted in our hospital from February 2010 to December 2012.The information of pregnant women and her infants who were very preterm infants were selected as study objects and the full-term babies in the corresponding period were control group. Results：A total of 98 very preterm births were included in this study. Unconditional logistic regression showed that Multiple births（OR=13.592,95%CI：7.015-26.333）,maternal gestational hypertension（OR=4.15,95%CI：2.339-7.363）,younger mothers（age〈25 years）（OR=2.072,95%CI：1.224-3.507）,maternal smoking（OR=1.796,95%CI：1.162-2.776）were association with a risk of very preterm births. But maternal higher education level（OR=0.384,95%CI：0.203-0.725）. Conclusion：In order to reduce the incidence of very preterm birth,we should detection of high risk factors of it in the earlier period of antenatal examination.