多囊卵巢综合征合并肥胖与单纯性肥胖者在IVF-ET中的临床结局相比较

Polycystic ovary syndrome combined with obesity and obese people in IVF-ET in clinical outcomes compared

目的探讨多囊卵巢综合征(PCOS)与体重指数对体外受精-胚胎移植(IVF-ET)临床结局的影响。方法在IVF-ET中根据体重指数BMI≥25和<25分为A组(肥胖)和B组,A组中合并PCOS的为A1组(100人),非PCOS(350人)为A2组,B组中合并PCOS为B1组(116人),非PCOS为B2组(600人)。所有患者的年龄≤35岁,PCOS与非PCOS一般情况匹配。比较各组的着床率、临床妊娠率、早期流产率、活产率。结果 A1、A2、B1、B2 4组的临床妊娠率相似(44.0%v49.0%v44.8%v49.0%),但是AI组早期流产率(27.3%v12.3%v7.7%v10.0%)和活产率(16.0%v35.4%v41.4%v35.2%),与其它三组的相比均显著性降低(16.0%v35.4%v41.4%v35.2%),P<0.05,而其它三组(A2组、B1组和B2组)的流产率和活产率相似,差别无统计学意义。结论年轻患者中,PCOS合并肥胖影响妊娠结局,而瘦型PCOS、单纯性肥胖对临床结局影响不大。

Objective：To investigate the polycystic ovarian syndrome（PCOS）and the effect of body mass index（BMI）on the outcome of in vitro fertilization-embryo transfer（IVF-ET）. Methods：According to body mass index BMI≥ 24 and 24,patients were divided into group A（obese）and group B in IVF-ET.A group merged PCOS is A1 group（100 people）,a nonPCOS（350 people）is A2 group,B group merged PCOS is B 1 group（116 people）,as non-PCOS is group B2（600 people）. All patients age is ≤ 35 years,the general condition of PCOS and non-PCOS is matched. Compareing the implantation rate,clinical pregnancy,miscarriage rate,live birth rate in each group. Results：The clinical pregnancy rates of four groups（A1,A2,B1,B2）were similar（44.0% v49.0% v44.8% v49.0%）, However,the early abortion rate（27.3% v12.3% v7.7% v10.0%）and live births of AI group were both significantly lower（16.0% v35.4% v41.4% v35.2%）compared with the other three groups,P〈0.05,while the live birth rates of the other three groups（A2 group,B1 and B2 group group）were similar.Conclusion：Younger patients,PCOS with obesity affect pregnancy outcomes,and simple overweight or obese has little effect on clinical outcomes.