血型不规则抗体在良、恶性肿瘤患者中的分布

Distribution of irregular blood type antibodies in benign and malignant tumors

目的探讨肿瘤患者不规则抗体的检出率及良、恶性肿瘤分布特点。方法对新疆医科大学附属肿瘤医院2014年1月-2014年12月14 400例肿瘤患者行ABO血型不规则抗体的测定,比较良、恶性肿瘤患者血型不规则抗体的阳性率及血型不规则抗体在良、恶性肿瘤患者中的分布特点。结果共14 400患者进行血型不规则抗体测定,其中良性肿瘤患者12 220例,恶性肿瘤患者2 180例,恶性肿瘤患者不规则抗体阳性率高于良性肿瘤患者(P<0.05)。12 220例良性肿瘤患者中女性患者筛选出不规则抗体阳性率高于男性(P<0.05);有输血史患者不规则抗体阳性率高于无输血史患者(P<0.05);女性有妊娠史患者不规则抗体阳性率高于女性无妊娠史患者(P<0.05)。2 180例恶性肿瘤患者中女性患者不规则抗体阳性率高于男性(P<0.05);有输血史患者不规则抗体阳性率高于无输血史患者(P<0.05);女性有妊娠史患者不规则抗体阳性率高于女性无妊娠史患者(P<0.05);有化疗史患者不规则抗体阳性率与无化疗患者筛选出不规则抗体阳性率比较差异无统计学意义(P>0.05)。结论不规则抗体阳性率与性别、输血、妊娠有关,恶性肿瘤患者更容易检出不规则抗体阳性,在工作中要对其提高重视,避免漏检,保障输血安全。

Objective To analyze the detection rate of irregular antibody in tumor patients and the distribution of benign and malignant tumors.Methods The determination of ABO blood group irregular antibody was performed in 14 400 cases of tumor patients hospitalized from January 2014 to December 2014 in Xinjiang Medical University Affiliated Tumor Hospital.the positive rate of irregular blood antibody and the distribution of blood group irregular antibody in benign and malignant tumor patients were compared and analyzed.Results A total of 14 400 patients were randomly divided into benign tumor patients and malignant tumor patients,with 12 220 cases of patients in benign tumor group and 2180 cases being in malignant tumor group.The positive rate of irregular antibody was higher in malignant tumor patients than that in benign tumor patients（P〈0.05）.In 12 220 patients with benign tumors,the positive rate of irregular antibody was higher in female patients than that in male patients（P〈0.05）;the positive rate of irregular antibody in patients with blood transfusion was higher than that in patients without blood transfusion（P〈0.05）;the positive rate of irregular antibody in women with pregnancy history was higher than that in women without pregnancy（P〈0.05）.In 2 180 patients with malignant tumor,the positive rate of irregular antibody was higher in female patients with benign tumor than that in male patients（P〈0.05）;the positive rate of irregular antibody in patients with blood transfusion was higher than that in patients without blood transfusion（P〈0.05）;the positive rate of irregular antibody in women with pregnancy history was higher than that in women without pregnancy（P〈0.05）;there was no difference between the patients with chemotherapy history and those with no history of chemotherapy in the positive rate of irregular antibody（P〈0.05）.Conclusion The positive rate of irregular antibody was related to sex,blood transfusion and pregnancy.Malignant tumor patients are more likely to detect irregular antibodies.They should pay attention to them at work,avoid missed diagnosis and ensure the safety of blood transfusion.