瓜蒌薤白半夏汤结合血府逐瘀汤治疗冠心病心绞痛的临床分析

Clinical Observation on Gualou Xiebai Banxia Decoction and Xuefu Zhuyu Decoction in the Treatment of Angina Pectoris

目的探讨瓜蒌薤白半夏汤结合血府逐瘀汤治疗冠心病心绞痛的临床效果。方法选择2013年8月—2016年1月在北京中医医院顺义医院住院的冠心病心绞痛病人96例,根据随机数字表法分为观察组与对照组,各48例。在基础治疗上,对照组给予血府逐瘀汤治疗,观察组给予瓜蒌薤白半夏汤结合血府逐瘀汤治疗,治疗观察28d。结果观察组与对照组心绞痛有效率分别为97.9%和85.4%,观察组明显高于对照组(P<0.05),两组治疗期间无不良反应发生。观察组治疗后心绞痛发作频率与心绞痛持续时间分别为(2.84±0.44)次/周和(2.75±0.53)min,而对照组分别为(4.55±0.61)次/周和(4.92±0.61)min,观察组明显低于对照组(P<0.05),且都明显低于治疗前(P<0.05)。观察组与对照组治疗后血清C反应蛋白(CRP)值分别为(2.42±0.13)mg/L和(3.09±0.24)mg/L,明显低于治疗前,观察组治疗后血清CRP值明显低于对照组(P<0.05)。两组治疗后的总胆固醇(TC)、三酰甘油(TG)与低密度脂蛋白胆固醇(LDL-C)含量明显降低,而高密度脂蛋白胆固醇(HDL-C)含量明显增加,与治疗前对比差异明显(P<0.05),同时治疗后观察组的TC、TG、LDL-C与HDL-C含量与对照组对比差异有统计学意义(P<0.05)。结论瓜蒌薤白半夏汤结合血府逐瘀汤治疗冠心病心绞痛能通过干预血脂代谢、调节CRP的表达,促进临床疗效提高,最终改善冠心病心绞痛的临床症状。

Objective To investigate clinical effects of Gualou Xiebai Banxia decoction（GXBD）and Xuefu Zhuyu decoction（XZD）in the treatment of angina pectoris.Methods Ninety-six patients with angina pectoris in Shunyi Hospital of Beijing Chinese Medicine Hospital from August 2013 to January 2016 were selected and randomly divided into two groups：control group（n =48）treated with XZD,and treatment group（n =48）treated with GXBD and XZD for 28 days.Results The effective rates of angina pectoris was 97.9%in treatment group,which was significantly higher than that in control group（85.4%,P 0.05）.There was no adverse reaction in two groups during the treatment.The angina attack frequency of angina pectoris and durations after treatment were 2.84±0.44 times per week and 2.75 min±0.53 min in treatment group,4.55 ±0.61 times per week and 4.92 min±0.61 min in control group,which was lower in treatment group than that in control group（P 0.05）.After treatment,serum C-reactive protein（CRP）values were lower than that in two groups before treatment,which was lower in treatment group than that in control group（P 0.05）.The contents of TC,TG and LDL-C were decreased significantly after treatment in two groups,while HDL-C contents were significantly increased in two groups（P 0.05）.There was difference in the contents of TC,TG,LDL-C and HDL-C between two groups after treatment（P0.05）.Conclusion GXBD and XZD can improve blood lipid metabolism,regulate CRP expression,improve clinical symptoms of angina pectoris and promote the clinical efficacy in patients with angina pectoris.