严重创伤失血多器官功能不全综合征患者胰岛β细胞功能与感染炎症和主要脏器功能的相关性

Relationships between isletβ-cell function and infection,inflammation and major organ function in multiple organ dysfunction syndrome patients with severe traumatic hemorrhage

目的分析严重创伤失血多器官功能不全综合征(MODS)患者胰岛β细胞功能与感染炎症及主要脏器功能之间的关系。方法选取2013年1月至2016年1月解放军第九四医院住院部收治的各种创伤MODS患者187例,按结局分为MODS生存组(MODS-S组,104例)和MODS病死组(MODS-D组,83例);另选取同期体检健康者100例作为对照组。测定3组空腹时血糖(GLU0)和胰岛素(INS0)水平,糖负荷30 min后血糖(GLU30)和胰岛素(INS30)水平,以及血可溶性髓样细胞触发受体-1(sTREM-1)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、丙氨酸氨基转移酶(ALT)、肌酐(Cre)和肌酸激酶同工酶(CK-MB)等指标水平;以稳态模式评估法胰岛素分泌指数(HOMA-β)和糖负荷30min后胰岛素增量和血糖增量比值(ΔINS30/ΔGLU30)评估胰岛β细胞功能,并分析与其他各项指标的关系。结果 MODS-D组HOMA-β和ΔINS30/ΔGLU30均明显低于MODS-S组,sTREM-1、TNF-α、IL-6、ALT、Cre、CK-MB水平均明显高于MODS-S组,差异均有统计学意义(P<0.01);严重创伤失血MODS患者HOMA-β和ΔINS30/ΔGLU30分别与血sTREM-1、TNF-α、IL-6、GLU0、ALT、Cre及CK-MB呈明显负相关(r=-0.356 4、-0.532 1、-0.345 8、-0.772 1、-0.762 5、-0.684 8、-0.606 4,r=-0.428 5、-0.567 8、-0.487 0、-0.743 6、-0.781 7、-0.717 6、-0.640 1,P<0.01)。结论严重创伤失血MODS患者存在胰岛β细胞功能不全,可以作为患者预后的诊断指标。

Objective To analyse the relationships between islet β-cell function and infection, inflammation and major organ function in multiple organ dysfunction syndrome （MODS） patients with severe traumatic hemorrhage. Methods A total of 187 cases of MODS patients hospitalized in the 94th Hospital of PLA from January 2013 to January 2016 were selected,and were divided into the MODS survival group （MODS-S group,104 cases） and MODS dead group （MODS-D group）. Other 100 healthy subjects were selected as the control group. The fasting blood glucose （GLU0） and insulin （INS0） levels,blood glucose （GLU30） and insulin （INS30） levels after 30 min of glucose loading,and levels of soluble triggering receptor expressed on myeloid ceils-1 （sTREM-1）, tumor necrosis factor-α （TNF-α）, interleukin-6 （IL-6）, alanine aminotransferase （ALT）, creatinine （Cre） and creatine kinase isoenzyme （CK-MB） in different groups were determined. The insulin-β-cell function was evaluated by homeostasis model assessment of β-cell function （HOMA-β） index and ratio of insulin increment and blood glucose increment after 30 min of glucose loading （△INS30/△GLU30）, and their relationships to other indexes, including sTREM-1, TNF-α, IL-6, GLU0, ALT, Cre and CK-MB, in MODS patients with severe traumatic hemorrhage were analysed. Results The HOMA-β and △INS30/△GLU30 ratio in the MODS- D group were lower than those in the MODS-S group, and levels of sTREM-1 ,TNF-α, IL-6, ALT, Cre and CK-MB in the MODS-D group were higher than those in the MODS-S group,there were statistically significant differences （P〈0.01）. In MODS patients with severe traumatic hemorrhage, HOMA-β and △INS30/△GLU30 was both negatively correlated with sTREM-1, TNF-α, IL-6, GLUo, ALT,Cre and CK-MB （r= -0. 356 4,-0. 532 1, -0.345 8,-0, 7721, -0. 762 5,-0. 684 8,-0. 606 4;r=-0. 428 5, -0. 567 8,-0. 487 0,-0. 743 6,-0.781 7, -0.717 6; -0. 640 1,P〈01 01）. Conclusion MODS patients With severe traumatic hemorrhage have islet β-cell dysfunetion Which may be used as a prognostic and diagnostic indicator.