摘要
由于近年来性传播疾病的流行,治疗淋病的药物青霉素及壮观霉素先后出现了耐药菌株,因此寻找治疗淋病的有效新药非常必要。1980年Dobck等报道2-乙酰吡啶缩氨硫脲衍生物对淋球菌和金黄色葡萄球菌的抑菌效果。
12 Compounds of pyrazine-carbazides were synthesized and characterized. These compounds were screened for their antibacterial properties against Bacillus subtilis 6633, Staphylococcus aureus 209p, Escherichia coli, Pseudomonas aeruginosa and Neisseria gonorrhoeae 29106-3. The results of testing for antibacterial activity revealed that the compounds Ⅷ 1, 2, 4, 7, 8, 9 10, 11, 12 had inhibited the growth of Pseudomonas aeruginosa at concentration of 50—25 μg/ml. Poor or no antibacterial activity was shown toward the other bacterial genera.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
1991年第4期233-235,共3页
Journal of China Pharmaceutical University
关键词
吡嗪酰氨硫脲
合成
淋球菌
Pyrazine-carbonyl thiosemicarbazieds
Neisseria gonorrhoeae
Bacillus subtilis