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吡嗪酰氨硫脲衍生物的合成

Synthesis of Pyrazine-Carbonyl Thiosemicarbazides
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摘要 由于近年来性传播疾病的流行,治疗淋病的药物青霉素及壮观霉素先后出现了耐药菌株,因此寻找治疗淋病的有效新药非常必要。1980年Dobck等报道2-乙酰吡啶缩氨硫脲衍生物对淋球菌和金黄色葡萄球菌的抑菌效果。 12 Compounds of pyrazine-carbazides were synthesized and characterized. These compounds were screened for their antibacterial properties against Bacillus subtilis 6633, Staphylococcus aureus 209p, Escherichia coli, Pseudomonas aeruginosa and Neisseria gonorrhoeae 29106-3. The results of testing for antibacterial activity revealed that the compounds Ⅷ 1, 2, 4, 7, 8, 9 10, 11, 12 had inhibited the growth of Pseudomonas aeruginosa at concentration of 50—25 μg/ml. Poor or no antibacterial activity was shown toward the other bacterial genera.
出处 《中国药科大学学报》 CAS CSCD 北大核心 1991年第4期233-235,共3页 Journal of China Pharmaceutical University
关键词 吡嗪酰氨硫脲 合成 淋球菌 Pyrazine-carbonyl thiosemicarbazieds Neisseria gonorrhoeae Bacillus subtilis
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参考文献1

  • 1徐开堃,王翠亨,霍(女贞)(女贞).抗结核药吡嗪酰胺(Pyrazinamide)的试制[J]化学世界,1957(04).

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