丁丙诺啡透皮贴剂控制肩周炎患者疼痛的效果观察

Observation on the Effect of Buprenorphine Transdermal Patch on the Pain of Patients with Scapulohumeral Periarthritis

目的:探讨丁丙诺啡透皮贴剂治疗肩关节周围炎的患者对于疼痛的缓解效果和肩关节活动功能的改善作用。方法:搜集本院近5年来门诊就诊及住院治疗的肩周炎患者152例,全部患者均规范化按照VAS评分使用镇痛药物。其中,78例患者在达到中度及以上疼痛水平时,额外加用丁丙诺啡透皮贴剂。每隔3月通过电话随访量化患者疼痛评分变化情况,门诊随访检查患者肩关节活动功能,并使用Constant-Murley肩关节功能评分量表进行数字化评估。结果:152例肩周炎患者在治疗观察期间,疼痛及肩关节活动功能均有一定程度的缓解和改善,在观察期末,平均Constant-Murley肩关节功能评分保持于80分水平。在治疗观察期内,外用丁丙诺啡透皮贴的患者在6-18月期间时,Constant-Murley肩关节功能评分上升速度明显高于对照组(P<0.05)。结论:丁丙诺啡透皮贴剂可以加快肩周炎患者的康复速度,提升肩周炎患者在治疗期间的生活质量。

Objective： To evaluate the effect of using buprenorphine transdermal patch in the treatment of patients with periarthritis of shoulder. Methods： 152 cases of periarthritis of shoulder in outpatient and inpatient treatment in our hospital were collected in recent 5 years. All patients were standardized using analgesics according to the VAS score. Buprenorphine transdermal patch was added in 78 patients with moderate to severe pain. All the patients were followed up by telephone in every 3 months to quantify the changes of pain score, and the shoulder joint fimction was examined by using Constant-Murley shoulder function score scale at each time of outpatient follow-up. Results： 152 cases of scapulohumeral periarthritis patients were observed. Pain and shoulder joint function of the whole patients has a certain degree of mitigation and improvement. In the end of the observation, the average Constant-Murley score was up to 80 points. In the observation period, the Constant-Murley shoulder function score in the buprenorphine transdermal patch group is obviously higher than control group in the time of 6 to 18 months （P〈0.05）. Conclusions： Through using buprenorphine transdermal patch, it can speed up the rehabilitation and improve the quality of life of patients suffered from periarthritis of shoulder.