实验性糖尿病足大鼠模型的研究进展

Research progress of diabetic foot rat model

动物模型具有可控性高、依从性好、可操作性强、价格廉价等优点。糖尿病足发病原因复杂,可由血管病变、神经病变及感染等因素单一或共同作用导致,很难有一种模型能完全模拟整个发病过程。目前公认的糖尿病大鼠造模方法是高脂饮食与链脲佐菌素诱导结合法,较常用的足溃疡造模方法是外科手术切除足部皮肤法。

Animal model has the advantages of high controllability, good compliance, strong operability, low price and so on. Morbidity of diabetic foot is complex, can be caused by vascular disease, neuropathy and infection factors such as single or joint action. It is difficult to have a model to simulate the whole process completely. At present, the accepted modeling method is high fat diet and streptozotocin combined technique which is induced by common foot ulcer model is surgical removal of the foot skin.