实验动物麻醉剂使用的福利伦理问题研究进展

Research progress on ethical issues of anesthetics application in laboratory animals

在进行动物实验时需要选择合适的麻醉剂来保证实验操作的顺利进行,获得可靠的实验数据,同时又将实验动物所遭受的痛苦降至最低,保证实验动物的福利。近年来,关于实验动物的福利伦理问题已越来越引起人们的关注。本文主要对动物实验常用的麻醉剂(包括吸入性麻醉剂:乙醚、七氟烷、异氟烷,非吸入性麻醉剂:戊巴比妥钠、水合氯醛、氯胺酮、乌拉坦)的选择及使用过程中可能存在的福利伦理问题做一综述。

Animal experiments are important methods for scientific research. During animal experiments, it is cru-cial to select the appropriate anesthetics, not only to ensure the smoothly performed operational procedure and obtaining re-liable experimental data, but also to avoid the suffering of laboratory animals and ensure their welfare as more as possible. In recent years, the ethical issues related to laboratory animal welfare have drawn more and more attention. In this review, we briefly discuss the selection of commonly used anesthetics during animal experiments, such as inhaled anesthetics, in-cluding diethyl ether, sevoflurane and isoflurane, as well as non-inhaled anesthetics, including pentobarbital sodium, chlo-ral hydrate, ketamine and urethane, and the possibly involved ethical issues related to the application of those anesthetics.