奥沙西泮与地西泮替代治疗酒精依赖的有效性和安全性对比

Comparison of the efficacy and safety of Oxazepam and Diazepam in alternative treatment of alcohol dependence

目的比较奥沙西泮与地西泮对酒精依赖替代治疗的有效性和安全性。方法将2015年1月~2017年5月我院收治的78例酒精依赖患者作为研究对象,将其随机分为两组,各39例。地西泮组采用地西泮进行治疗,奥沙西泮组采用奥沙西泮进行治疗。比较两组的总有效率,过度镇静、尿失禁等的总不良反应发生率;干预前后的汉密尔顿焦虑量表、汉密尔顿抑郁量表和戒断反应量表评分。结果奥沙西泮组的总有效率高于地西泮组(P<0.05);奥沙西泮组过度镇静、尿失禁等的总不良反应发生率低于地西泮组(P<0.05);干预前,两组的汉密尔顿焦虑量表、汉密尔顿抑郁量表和戒断反应量表评分差异无统计学意义(P>0.05);干预后,奥沙西泮组的汉密尔顿焦虑量表、汉密尔顿抑郁量表和戒断反应量表评分优于地西泮组(P<0.05)。结论奥沙西泮对酒精依赖替代治疗的有效性和安全性高于地西泮,可减少不良反应的发生,更好地改善患者的临床症状,减轻其不良情绪。

Objective To compare the efficacy and safety of Oxazepam and Diazepam in alcohol-dependent replacement therapy.Methods A total of 78 patients with alcohol dependence from January 2015 to May 2017 treated in our hospital were selected as study subjects and they were randomly divided into the two groups and there were 39 cases in each group.The Diazepam group was treated with Diazepam and the Oxazepam group was treated with Oxazepam.The total ef- fective rate and total incidence of adverse reactions such as excessive sedation,urinary incontinence and so on,and the score of Hamilton Anxiety scale,Hamilton Depression scale and the withdrawal response scale were compared before and after the intervention between the two groups.Results The total effective rate in the Oxazepam group was higher than that in the Diazepam group （P〈0.05）.The total incidence of adverse reactions such as excessive sedation and uri- nary incontinence and so on in the Oxazepam group was lower than that in the Diazepam group （P〈0.05）.The score of Hamilton Anxiety scale,Hamilton Depression scale and abstinence response scale had no statistical difference between the two groups before intervention （P〉0.05）,the score of Hamilton anxiety scale,Hamilton Depression scale and with- drawal response scale were better than those of the Diazepam group （P〈0.05）.Conclusion Oxazepam is superior to Di- azepam in the treatment of alcohol dependence,which can reduce the incidence of adverse reactions,improve the clini- cal symptoms and relieve the negative emotion.