聚乳酸、聚乳酸乙醇酸共聚物微球的制备及体外释放影响因素研究进展

Progresses in Preparation of PLA, PLGA Microspheres and their Influence Factors

目的 :对近年来以PLA、PLGA为载体的微球剂的研究进展进行综述。方法 :查阅近 10年来有关PLA、PLGA微球研究的国内外文献 ,介绍此类微球的制备方法和影响其体外释放等性质的主要因素。结果 :PLA、PLGA的性质、药物的性质及微球的制备工艺等对微球的体外释放等性质均有重要的影响。结论 :对以PLA、PLGA为载体制备的药物微球 。

OBJECTIVE:To review the development of PLA, PLGA microspheres in recent years. METHOD:The methods for the preparation of PLA, PLGA microspheres and the influence factors to drug release were sumerized. RESULTS:The characters of PLA, PLGA and drug, and the preparation had important effects to drug release from PLA, PLGA microspheres. CONCLUSION:It should be further studied on PLA, PLGA microspheres.