钇-90微球的特性、放射栓塞的操作技术及安全防护——钇-90微球放射栓塞系列回顾(一)

Characteristics of yttrium-90 microsphere, techniques and radiation safety of radioembolization procedure. A series review of radioembolization with yttrium-90 microspheres (partⅠ)

钇-90(90Y)微球放射栓塞是一种局部治疗方法 ,它将载有发射β射线的90Y树脂或玻璃微球选择性地注射到肝动脉。90Y微球随血流被阻塞在肿瘤血管床,其发出的射线对靶肿瘤具有细胞毒性作用。该方法的安全性和有效性已经在不可切除的肝脏恶性肿瘤患者中得到证实。本文作为90Y微球放射栓塞系列综述的第一部分,将讨论90Y和90Y微球的基本特性,90Y微球放射栓塞的基本操作方法 ,以及放射性安全与防护。

Radioembolization with yttrium-90 （^90Y） microspheres is a locoregional procedure during which either resin or glass microspheres loaded with β-emitting ^90Y are selectively injected into a hepatic artery. The microspheres are trapped in downstream vasculatures, at which point they deliver a eytotoxie dose of radiation to the target tumor. The safety and efficacy of this method have been demonstrated in studies of survival outcomes in patients with nonresectable hepatic malignancies. In this first part of a series of reviews on radioembolization with ^90Y microspheres, we cover the basic characteristics of ^90Y and ^90Y mierospheres, techniques for the radioembolization procedure, and methods for ensuring radiation safety and protection.