洛美沙星选择性电极的制备及应用

Preparation and application of selective electrode of lomefloxacin

目的 :制备一种以洛美沙星与四苯硼钠缔合物为活性物的PVC膜洛美沙星选择性电极。方法 :用此电极以标准曲线法对盐酸洛美沙星及二种制剂进行含量测定。结果 :电极的响应范围 10 1～ 10 5mol/L ,斜率为 5 1.4mV/pC ,测得平均回收率为 98.1% ,RSD =2 .6 % (n =8)。结论 :方法灵敏度高 ,操作简便 ,结果与HPLC法相符。

OBJECTIVE:A PVC membrane lomefloxacin(LFLX) selective based on LFLX and sodium tetrachenylborin molecular association complex is prepared. METHOD:The electrode has been used for the determination of LFLX and its preparations by standard curve method.RESULTS:The electrode exhibits response for LFLX with a slope of 51.4 mV/pC over the concentration range of 10 1 ～10 5 mol /L . The average recovery was 98.1% with a RSD of 2.6% ( n =8 ). CONCLUSION:The method has good sensitivity, and the procedures of this method is simple. The results obtained agreed with those by HPLC method.