甘精胰岛素联合口服降糖药治疗2型糖尿病磺脲类继发性失效临床观察

Clinical Observation on Insulin Glargine and Oral Administration of Hypoglycemic in Treatment of Secondary Failure of Sulfonylurea in Type 2 Diabetes Mellitus

目的研究甘精胰岛素联合口服降糖药治疗磺脲类继发性失效的2型糖尿病的临床疗效。方法选择该院2015年3月—2016年9月患有磺脲类继发性失效的2型糖尿病的临床病例80例进行分析,随机分为观察组和对照组,每组40例。对照组采取常规的治疗,观察组采取甘精胰岛素联合口服降糖药的方式治疗,所有患者在治疗前后12周测定空腹血糖(FBG)、餐后2 h的血糖值(2hBG)和糖化血红蛋白值(HbA1c),观察比较两组结果。结果两组患者治疗3个月后,空腹血糖(FBG)、餐后2 h的血糖值(2hBG)和糖化血红蛋白值(HbA1c)较治疗前明显降低,对于空腹血糖值而言,观察组明显高于对照组,差异有统计学意义(P<0.05);观察组治疗期间出现低血糖的例数明显低于对照组,差异有统计学意义(P<0.05)。结论采取甘精胰岛素联合口服降糖药治疗磺脲类继发性失效的2型糖尿病,能有效的控制血糖,低血糖发生率低,治疗安全性高,值得在临床上广泛使用。

Objective To research the clinical curative effect of insulin glargine and oral administration of hypoglycemic in treatment of Secondary failure of sulfonylurea in type 2 diabetes mellitus. Methods 80 cases of patients with secondary failure of sulfonylurea in type 2 diabetes mellitus in our hospital from March 2015 to September 2016 were selected and randomly divided into two groups with 40 cases in each, the control group adopted the routine treatment, while the observation group adopted the insulin glargine and oral administration of hypoglycemic, and the FBG, 2hBG and HbA1c were measured in 12 weeks before and after treatment, and the results were observed and compared. Results After three-month treatment,the FBG, 2hBG and HbA1c obviously decreased compared with those before treatment, and the FBG in the observation group was obviously higher than that in the control group, and the difference was statistically significant（ P〈0.05）; the hypoglycemia case in the observation group was obviously fewer than that in the control group, and the difference was statistically significant（ P〈0.05）. Conclusion The insulin glargine and oral administration of hypoglycemic in treatment of secondary failure of sulfonylurea in type 2 diabetes mellitus can effectively control the blood glucose and reduce the incidence rate of hypoglycemia with high treatment safety, which is worth wide application in clinic.