倍他乐克对高血压患者左心室肥厚及心功能的影响(英文)

Effect of Metoprolol on cardiac function and hypertensive left ventricular hypertrophy

目的 :观察倍他乐克降压及改善左心室肥厚的作用。方法 :6 1例高血压左室肥厚的患者 ,随机分为治疗组 31例 ,给予倍他乐克片 2 5～ 5 0mg ,每日 1～ 2次 ,对照组 30例 ,复方降压片 1片 ,每日三次。血压控制在正常或接近正常水平后 ,继续服药 12～ 16周 ,平均 13.2周。采用多普勒血流显像 ,用统计学处理方法 ,对照用药前后血压、心率、心室肥厚、心脏收缩及舒张功能。结果 :两组经治疗后血压显著下降 (P <0 .0 1) ,治疗组心率及外周阻力显著下降 (P <0 .0 5～ 0 .0 1) ,心房内径变小 (P <0 .0 1) ,左室重量指数降低 (P <0 .0 1)。左室舒张功能指标 :A峰降低 ,E峰增高 ,A/E比例降低 ,峰值充盈率及标准化峰值充盈率均升高 (P <0 .0 1)。结论 :倍他乐克在显著降压的同时 ,还可使肥厚的心肌发生逆转 。

OBJECTIVE:To study the effect of Metoprolol on cardiac function and hypertensive left ventricular hypertrophy.METHOD:Sixty one patients with hypertensive left ventricular hypertrophy were randomly divided into 2 groups, 31 in treatment group and 30 in control group. The patients in treatment group were given 25～50mg Metoprolol once or twice a day and the patients in control group were given 1 piece compound hypotensive once for three times a day, which should be used for 12 to 16 weeks with average of 13.2 weeks until blood pressure was controlled at or near critical level. Under color Doppler flow image, ventricular hypertrophy and cardiac function were compared before and after treatment with statistic method. RESULTS:It showed that HR, SBP, DBP and TPR were dropped down with total effective rate of 87% (P<0.01). Left ventricular morphosis criterion as LAD, LVD and LVMI were all obviously improved ( P <0.05～0.01). Left ventricular diastolic function criterion as A,E, A/E, PER and NPFR were also improved ( P <0.05). No changes occurred in left ventricular systolic criterion as SV, EF and CO ( P <0.05).CONCLUSIONS:Metoprolol can treat hypertension as well as improve cardiac diastolic function and left ventricular hypertrophy.