血浆FA、ET-1、Hcy、VEGF水平与妊娠高血压综合征的相关性研究

Relationship between Plasma FA,ET-1,Hcy and VEGF Levels and Pregnancy Induced Hypertension

目的:研究叶酸(FA)、内皮素(ET-1)、同型半胱氨酸(Hcy)和血管内皮生长因子(VEGF)与妊娠高血压综合征的相关性。方法:选择2013年1月~2016年9月在我院进行诊治的妊娠高血压综合征患者80例,分为妊娠期高血压组即A组(40例)以及子痫前期、子痫组即B组(40例),60例正常晚期孕妇为C组,60例正常非孕妇为D组,分别检测各组的血浆FA、ET-1、Hcy和VEGF水平,并进行相关性分析。结果:四组间血浆FA、ET-1和Hcy水平相比,B组的血浆FA和VEGF水平最低(P<0.05),ET-1和Hcy水平最高(P<0.05);妊娠高血压综合征的妇女血浆FA和VEGF水平均低于正常晚期孕妇,ET-1和Hcy水平明显高于正常晚期孕妇(P<0.05);多因素logistic回归分析显示FA、ET-1、Hcy、VEGF水平是妊娠高血压综合征的危险因素。结论:妊娠期FA缺乏引起血浆Hcy水平的升高可能与妊娠高血压综合征的发病及病情发展有关,VEGF可能是妊娠高血压综合征发生、发展的一个重要危险因素。

Objective：To investigate the relationship between FA,ET-1,Hcy and VEGF in patients with pregnancy induced hypertension.Methods：Selected 80 cases of patients with pregnancy induced hypertension who were treated in our hospital from January2013 to September 2016,divided into A group（40 cases）,and preeclampsia and preeclampsia B group（40 cases）,60 cases of normal late pregnant women as C group,60 cases of normal non pregnant women as D group.The plasma levels of FA,ET-1,Hcy and VEGF in each group were detected,and the correlation analysis was performed.Results：The plasma levels of FA and VEGF of group B were lowest in the four groups（P0.05）,the plasma ET-1 and Hcy levels of group B were highest（P0.05）.The plasma FA and VEGF levels of women with pregnancy induce hypertension were lower than those of the healthy late pregnant women.The plasma ET-1 and Hcy levels were higher（P0.05）.The multivariate logistic regression analysis showed that FA,ET-1,Hcy and VEGF levels were risk factors for pregnancy induce hypertension.Conclusion：The elevation of plasma Hcy level caused by FA deficiency in pregnancy might be related to the development of the disease and the incidence of pregnancy induced hypertension syndrome,VEGF might be an important factor in the occurrence and development of pregnancy induced hypertension syndrome.