摘要
目的:研究血清中降钙素原在病毒性感染、一般性细菌感染和重症细菌性感染患者中的应用价值。方法:选择2014年6月~2016年12月在我院重症医学科进行诊治的感染患者60例,按照患者感染的严重程度分为病毒性感染患者(A组)15例,一般细菌感染组(B组)22例以及重症细菌性感染组(C组)23例。三组患者均采取纠正水电解质平衡、抗生素抗感染和营养支持等对症治疗,并在入院后第1、3、5、7 d检测患者的血清降钙素原水平,比较三组治疗前后血清降钙素原水平的差异,观察三组血清降钙素原≥0.5μg/L的例数。结果:B组血清降钙素原≥0.5μg/L的例数为20例,占90.91%,C组血清降钙素原≥0.5μg/L的例数为21例,占91.30%,B组和C组之间相比无明显差异(P>0.05),但A组血清降钙素原≥0.5μg/L的例数为3例,占20.00%,明显低于B组和C组血清降钙素原≥0.5μg/L的例数,差异均具有统计学意义(P<0.05);C组入院后第1、3、5、7 d的血清降钙素原水平均明显高于B组的血清降钙素原水平,差异均具有统计学意义(P<0.05);重症细菌性感染患者中,血清降钙素原≥0.5μg/L的患者存活率明显低于血清降钙素原<0.5μg/L的患者(P<0.05)。结论:血清中降钙素原水平对于重症感染患者的临床诊断和治疗具有较好的应用价值,对于医生判断重症感染患者的预后情况具有很好的效果,值得临床广泛应用推广。
Objective：To investigate the application value of serum procalcitonin in patients with viral infection,bacterial infection and severe bacterial infection.Methods：Selected 60 cases of patients with infection who were treated in our hospital from June 2014 to December 2016,divided into three groupsaccording to the severity of the infection,viral infection（group A） 15 cases,general bacterial infection（group B） 22 cases,and severe bacterial infection（group C） 23 cases.Three groups of patients were treated with symptomatic treatment,and after admission,the serum procalciton in levels were detected in 1,3,5,7 d,and compared with the serum procalcitonin levels before and after treatment in the three groups.Results：The serum procalcitonin ≥0.5 μg/L number of B group and C group had no significant difference（P0.05）,the serum procalcitonin ≥0.5 μg/L number of A group was significantly lower than that of B group and C group（P0.05）;the survival rate of severe bacterial infection patients whose serum procalcitonin was higher than than 0.5μg/L was significantly higher than those who with serum procalcitonin lower than 0.5 μg/L（P0.05）.Conclusion：Serumprocalcitonin level had a good application value in the clinical diagnosis prognostic prediction of patients with severe infection.
出处
《现代生物医学进展》
CAS
2017年第27期5338-5340,5384,共4页
Progress in Modern Biomedicine
