胰腺癌患者循环肿瘤细胞及TLR4、TLR9、myd88的表达水平与其化疗效果及转移、复发的关系

Expressions of TLR4, TLR9 and myd88 Signaling in CTC of Patients with Pancreatic Carcinoma and Its Relationship with Chemotherapy,Metastasis and Recurrence

目的:探讨胰腺癌患者循环肿瘤细胞(CTC)中Toll样受体4(TLR4)、Toll样受体9(TLR9)、髓样分化因子88(myd88)的表达水平与患者化疗效果及转移、复发的关系。方法:将我院2015年6月-2016年6月收治并确诊的48例胰腺癌患者作为试验组,收集患者循环肿瘤细胞(CTC),检测其TLR4、TLR9、myd88信号表达情况,探讨其TLR4、TLR9、myd88信号表达水平与患者化疗效果及转移、复发的关系。结果:48例胰腺癌患者检出CTC 35例,检出率为72.9%。胰腺癌死亡、转移、复发患者TLR4、TLR9、myd88表达水平分别高于其存活、未转移、未复发患者,组间具有统计学差异(P<0.05)。胰腺癌化疗效果CR患者TLR4、TLR9、myd88表达水平显著低于其化疗效果PR、SD、PD患者,且四组间差异具有统计学意义(P<0.05);TLR4、TLR9、myd88表达水平与被膜受侵犯、淋巴结转移、肿瘤大小、CA199水平呈正相关(P<0.05)。结论:胰腺癌患者CTC中TLRs/myd88信号表达水平与患者化疗效果及转移、复发密切相关。

Objective： To investigate the expression of TLRs / myd88 signal in CTC of patients with pancreatic cancer and the relationship between chemotherapy and metastasis and recurrence. Methods： 48 cases with pancreatic cancer had treated and diagnosed in June 2015 to June 2016 were selected as the experimental group. The expression of TLRs and myd88 and the relationship between the expression of TLRs and myd88 waS observed. Results： 35cases of CTC were detected in 48cases of pancreatic cancer. The detection rate was 72.9%. Pancreatic cancer death, metastasis, recurrence in patients with TLR4, TLR9 and myd88 expression levels were higher than the survival, without metastasis, without recurrence, and the difference was statistically significant （P 〈0.05）. pancreatic cancer chemotherapeutic effect CR of TLR4, TLR9 and myd88 expression level was significantly lower than chemotherapy PR, SD and PD patients, and the differences between the four groups was statistically significant （P 〈0.05）; TLR4, TLR9 and myd88 were positively correlated with the invasion, lymph node metastasis, tumor size and CA199 level （P〈0.05）. Conclusion： The expressions of TLRs / myd88 in CTC of patients with pancreatic cancer is closely related to the effect of chemotherapy and metastasis and recurrence.