双酚A对原始卵泡池动态变化影响机制的研究进展

Effects of bisphenol A on the dynamic changes of primordial follicle pool:mechanism research progress

原始卵泡是女性的基本生殖单位,也是卵母细胞储备的唯一形式。如果原始卵泡产生的数量不足,被过度、过早激活或发生闭锁,都可能导致早发性卵巢功能不全(POI)。导致POI的病因多且复杂,环境内分泌干扰物(EED)对POI等女性生殖系统疾病的影响作用,受到研究者关注。双酚A为重要的EED之一,具有弱雌激素活性。目前研究结果显示,双酚A对原始卵泡池的动态变化有一定影响。因此,笔者拟就双酚A对原始卵泡池动态变化影响机制的最新研究进展进行综述,旨在为与双酚A相关的POI等女性生殖系统疾病的预防和治疗,提供理论依据。

Primordial follicle is the basic reproductive unit of women,also the only reservation form for oocyte.If the generated number of primordial follicles are insufficient,or being excessively,prematurely activated or follicular atresia occured,premature ovarian insufficiency（POI）may occur.The causes of POI are many and complicated,and the effects of environmental endocrine disruptors（EED）on POI and other diseases of female reproductive system have attracted attention of researchers.Bisphenol A,one of typical EED,has weak estrogenic activity.Accumulating evidence has suggested that bisphenol A has effects on the dynamics of primordial follicle pool.In this article,we review the latest research progress of the mechanism of bisphenol A effects on the dynamics of primordial follicle pool,to provide theoretical basis for prevention and treatment of POI and other diseases of female reproductive system.