PI3K-Akt3信号通路在心脏发育中的作用

Roles of PI3K-Akt3 signaling pathway during cardiac development

PI3K-Akt3信号通路是广泛存在于真核生物中高度保守的信号通路.PI3K-Akt3信号通路通过促进心肌细胞的生长和存活、促进冠脉血管新生、维持心脏收缩功能、调节信号转导和诱导细胞自噬等途径,在心脏发育中发挥重要作用。笔者拟就PI3K-Akt3信号通路对心脏发育影响的最新进展进行综述。

PI3K-Akt3 is a highly conservative signaling pathway,which exists widely in eukaryotes.PI3K-Akt3 signaling pathway plays an important role during cardiac development through the following ways：promoting cardiomyocyte growth and survival,promoting coronary angiogenesis,enhancing cardiac contractility,regulating signal transduction,inducing autophagy.In this review,we focus on the recent research progress about the roles of PI3K-Akt3 signaling pathway during cardiac development.