骨关节炎与MAPK信号通路关系的研究概况

Research Progress on the Relationship between Osteoarthritis and MAPK Signaling Pathway

丝裂原活化蛋白激酶(MAPK)是生物体内重要的细胞信号传递途径之一,参与调节细胞功能活动。MAPK信号通路包括多个亚家族如细胞外信号调节蛋白激酶(ERK)通路、氨基末端激酶(JNK)通路、P38MAPK等。ERK、JNK、P38信号传导途径被活化后参与骨关节炎软骨细胞的增殖、凋亡与分化反应,加速骨关节炎软骨组织病理性降解,导致骨关节炎(Osteoarthritis,OA)的发生。文章对近年来OA与MAPK信号通路关系进行综述。

Mitogen activated protein kinase is an important cell signaling pathway involved in the regulation of cell function aetivity of. MAPK signal pathway comprises a plurality of sub family such as ERK, JNK, p38MAPK. ERK, JNK, activation of P38 signaling pathway in osteoarthritis cartilage cell proliferation, apoptosis and differentiation reaction, accelerate osteoarthritic cartilage pathological degradation, resulting in osteoarthritis the occurrence of OA. In recent years, the relationship between OA and MAPK signaling pathway is summarized as follows.