中医周期疗法治疗不孕症的用药规律及作用机制探析

Analysis on Medication Regularity and Action Mechanism of Infertility with Traditional Chinese Medicine Periodic Therapy

目的:应用数据挖掘方法分析和总结文献中中医周期疗法治疗不孕症的分期用药规律,探讨其作用机制的关键点。方法:检索1980—2016年有关中医周期疗法治疗不孕症的临床研究文献,建立Excel数据库,运用SPSS Clementine 12.0软件对数据进行处理分析。结果:共纳入文献85篇,涉及中药143味,应用频数共计3 609次。总结分期治疗的高频药物及组合规律,"补肾"贯穿治疗始终。结论:中医周期疗法治疗不孕症的分期治则治法为经后期益精养血,经间期活血化瘀、调畅血脉,经前期温肾助阳,月经期活血祛瘀生新。结合天癸相关理论,提出调肾中之天癸是中医周期疗法治疗不孕症的关键点。

Objective： Data mining method was adopted to summarize the medication regularity in each phase and the action mechanism of infertility with traditional Chinese medicine（ TCM） periodic therapy. Method：Clinical research literatures of treatment for infertility by TCM periodic therapy in 1980—2016 were searched,a database of Excel was established and SPSS Clementine 12. 0 software was used to analyze the data. Result： A total of 143 TCMs and 3 609 frequencies were involved in the 85 literatures. Sumed up the TCMs with high usage frequency in the prescriptions for each phase. The result preliminary proved that tonifying the kidney was used throughout the TCM periodic therapy. Conclusion： The main rules of treatment in post menstrual period are nourishing the essence and enriching the blood,in ovulation are promoting blood circulation for removing blood stasis and regulating blood vessels,in premenstrual phase are warming kidney and activating Yang,in menstrual period are promoting blood circulation and removing blood stasis for promoting tissue regeneration. The key point of TCM periodic therapy for infertility is regulating Tiangui in the kidney.