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应激时NMDA受体活性变化对HPA轴兴奋性的影响研究进展 被引量:3

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摘要 现代的应激概念认为,应激是个体面临或察觉到环境变化(应激原)对机体有威胁或挑战时作出的适应和应对的过程,下丘脑-垂体-肾上腺(HPA)轴的兴奋是其主要的神经内分泌改变,糖皮质激素是最主要的应激激素之一.Robert M[1]在总结了相关的资料认为:应激过度导致机体持续升高的糖皮质激素可引起创伤后应激不良综合症(PTSD).应激时糖皮质激素过度升高的机制是复杂的.近年来,人们发现N-甲基-D-天冬氨酸(N-methyl-D-aspartate,NMDA)受体的变化与糖皮质激素水平关系密切,本文重点综述应激反应时NMDA受体对HPA轴的影响尤其是对糖皮质激素水平的影响以及应激时NMDA受体活性的调控.
出处 《西南国防医药》 CAS 2002年第4期367-370,共4页 Medical Journal of National Defending Forces in Southwest China
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