微生物共培养在新活性化合物挖掘中的研究进展

Progress of microbial co-culture in new compound mining

微生物次级代谢产物结构新颖、活性多样,一直以来都是药物及其先导化合物的重要来源。但近年来在普通微生物纯培养中发现的新活性物质不断减少,重复发现逐渐增加;而微生物共培养因更加接近微生物生长的自然环境,在药物及其先导物挖掘方面发挥着越来越重要的作用。本文分析了近5年来利用真菌vs真菌、真菌vs细菌共培养挖掘新活性化合物的研究现状,以及研究中存在的问题。

Microbial secondary metabolites have been an important source of drugs and their leading compounds because of their novel chemical structures and various biological activities. However, in recent years, there is a high frequency of re-discovery and a low frequency of new discovery of active compounds from microbial pure culture. As microbial co-culture is closer to the natural environment of microbial growth, it plays an important role in new compound mining. Here, we review the progress of new compound mining through co-culture from fungi vs fungi and fungi vs bacteria, and the current problems of this field for future research is also mentioned.