摘要
目的:将氨甲苯酸注射液与临床常用联合注射液组成配伍溶液,研究其配伍稳定性。方法:模拟临床联合用药配置方法,组成氨甲苯酸注射液与其他配伍药物的混合溶液,观察其6小时内的外观、含量、p H值、可见异物及不溶性微粒变化。结果:各配伍溶液在室温放置6小时的外观、含量、p H值、可见异物及不溶性微粒均无明显变化,含量均在(平均值±0.5)范围内波动,RSD均小于1%。结论:氨甲苯酸注射液与头孢替安、头孢硫脒、五水头孢唑啉、依替米星、血栓通、马来酸桂派齐特、磷酸肌酸、红花注射液配伍稳定,临床上可以安全配伍。
Objective: To compound PAMBA Injection and common variety drugs, and study the compatible stability. Methods: Clinical combination configuration method was simulated, and the mixed solution was prepared using PAMBA Injection and common variety drugs. The appearance, content, pH value, visible and insoluble particles changes were observed after 6 h. Results: After stored 6 h at room temperature, the appearance, content, pH value, visible and insoluble particles had no obvious change. The content fluctuated within(average±0.5), and the RSD was less than 1%. Conclusion: The compatibility of PAMBA Injection and Cefotiam, Cefathiamidinem, Cefazolin pentahydrate, Etimicin, Xueshuantong, Ginepazide Maleat, Safflor injection is stable respectively. The drug solution can be mixed safely.
出处
《中国药物滥用防治杂志》
CAS
2017年第5期278-281,共4页
Chinese Journal of Drug Abuse Prevention and Treatment