Klotho在动物肾脏疾病中的作用机制

Roles of Klotho in animal renal diseases

Klotho是一种I型单链跨膜蛋白,主要在肾脏和脑中表达,其表达产物可分为膜结合型蛋白和分泌型蛋白,在动物肾脏中两者均具有调节钙磷重吸收的作用,从而维持机体钙磷平衡。大量研究表明,Klotho在动物肾脏疾病的发生和发展过程中起着重要的调节作用。Klotho作为一种肾脏保护因子,可以保护肾细胞、加速肾再生,并进而改善肾损伤症状并且减缓肾脏疾病的发生。本文主要从Klotho在动物肾脏中的钙磷重吸收作用、与动物肾脏疾病的关系及其对动物肾脏的保护机制等方面的研究现状作一综述,旨在为动物肾脏疾病的诊断和治疗提供新靶点。

Klotho is a kind of type I single chain transmembrane protein, which is mainly expressed in the kidney and brain, and the ex- pression products can be divided into membrane binding protein and secreted protein. Both of them have the function on regulating calcium and phosphorus absorption in the animal kidney, thus maintaining the balance of calcium and phosphorus in the body. A large number of studies have indicated that Klotho plays an important role in the occurrence and development of animal kidney diseases. As a kind of renal protective factor, Klotho can protect the kidney cells, accelerate the regeneration of kidney, and then improve the renal injury symptoms and slow down the occurrence of renal disease. In this paper, Klotho＇s function on calcium and phosphorus absorption in the animal kidney, its relationship with animal renal disease and the protective mechanism of the animal kidney were reviewed, in order to provide a new target for diagnosis and treatment of animal kidney disease.