治疗肝腹水中药专利的整体态势分析

Patent Analysis of Traditional Chinese Medicine in the Treating Liver Ascites

目的研究中药治疗肝腹水领域的专利文献,为该领域的新药研发提供文献参考。方法以中国专利数据库、SFDA网站为检索源,以肝腹水、肝硬化和中药为关键词,对1991—2017年公布或公开的专利申请进行检索,再通过人工降噪的方法确定最终肝腹水文献,以IPC分类、申请人类别、重点申请人、法律状态等特征进行分析。结果检索到肝腹水有关的中医药专利文献共计242篇,主要集中在A61大类中,有效专利占总专利数的12%,失效专利占到总专利数的65%,专利申请的主体以自然人为主,从专利申请增长率方面来看,该领域的专利申请趋势在逐年增大,但是截止目前为止还没有专门针对该类疾病的上市中成药,处于市场空白期。结论治疗肝腹水领域的有效专利数少,成果产业化低,目前在已上市中成药中还没有专门针对该类疾病药品,所以研制出具有自主知识产权治疗肝腹水的中药新药具有广阔的市场前景。

OBJECTIVE To study the patent literature of traditional Chinese medicine in the treatment of liver ascites, and to provide reference for new drug research and development in this field. METHODS According to the Chinese patent database, SFDA website as the retrieval source, liver ascites, cirrhosis and traditional Chinese medicine as the key words, the patent application published in 1991-2017 was searched, and then through artificial noise reduction. METHODS The final liver ascites literature was identified and analyzed by IPC classification, applicant type, key applicant, legal status and so on. RESULTS A total of 242 Chinese medicine patent documents were collected, including 12% of the total number of patents, 62% of the total number of patents, and 62% of the total number of patents. The main body of the patent application was natural. In terms of the growth rate of patent applications, the trend of patent applications in this area had increased year by year, but so far there had been no listing of proprietary Chinese medicines specifically targeted at such diseases. CONCLUSION There are few effective patent cases in the treatment of liver ascites, and the results are low in industrialization. At present, there are no drugs specifically listed in the listed Chinese medicine. Therefore, it has developed a market with independent intellectual property rights for the treatment of liver ascites. prospect.