深圳市女性HPV感染及血清叶酸水平与子宫颈病变的关系

Relationship Between HPV Infection,Serum Folate Levels and Cervical Lesions Among Women in Shenzhen

[目的]研究深圳市女性人乳头瘤病毒(human papillomavirus,HPV)感染及血清叶酸水平与子宫颈病变的关系,为宫颈癌的预防提供理论依据。[方法]选取2015年12月1日至2016年5月31日深圳市7家医院宫颈门诊病人为研究对象,其中,正常90人,CIN1有110例,CIN2+有136例。比较分析各组妇女HPV感染状态,血清叶酸水平及其与子宫颈病变的关系。[结果]随着子宫颈病变程度的加深,HPV感染率逐渐升高(χ~2_(趋势)=104.351,P<0.001)。正常组、CIN1组及CIN2+三个组间血清叶酸水平的差异有统计学意义(F=4.313,P=0.014),其中,CIN2+组与正常组及CIN1组比较差异具有统计学意义(P<0.05)。三组hr HPV+者血清叶酸水平间的差异具有统计学意义(F=6.843,P<0.001)。其中,CIN2+组与正常组及CIN1组比较差异具有统计学意义(P<0.05)。[结论]血清叶酸水平可能与子宫颈病变相关,且可能与HPV感染存在相加作用。

[Objective] To investigate the relationship between human papillomavirus（HPV） infection,serum folate levels and cervical lesions among women in Shenzhen. [Methods] Patients attending cervical outpatient clinics of 7 hospital in Shenzhen from December 2015 to May2016 were enrolled in the study,including 90 normal cases,110 CIN1 cases,and 136 CIN2 ＋cases. The relationship between HPV infection,serum folate levels and cervical lesions was analyzed. [Results] HPV positivity increased with the severity of the pathological result（χ~2_（trend）=104.351,P〈 0.001）. The serum folic acid levels among normal,CIN1 and CIN2 ＋ groups were significantly different（ F =4.313,P =0.014）;and also there was significant difference between CIN2＋ and normal groups,and between CIN2＋ and CIN1 groups（P〈0.05）. There were significant differences in serum folate levels of hr HPV ＋ women among normal,CIN1 and CIN2 ＋groups（F =6.843,P0.001）,and there was significant difference between CIN2 ＋ and normal groups,and between CIN2 ＋ and CIN1 groups（P 0.05）. [Conclusion] Serum folic acid level may be associated with cervical lesions and HPV infection may have an addictive effect.