EGFR和PKB在宫颈癌中的表达和意义

Expression and Significance of EGFR and PKB in Cervical Cancer

[目的]探究表皮生长因子受体(epidermal growth factor receptor,EGFR)和蛋白激酶B(protein kinase B,PKB)在宫颈癌中的表达和意义。[方法 ]选取2014年1月至2016年1月于我院确诊为宫颈鳞癌并行手术治疗患者60例。另取正常宫颈组织20例作为对照组。采用免疫组化技术检测组织中的EGFR和PKB。[结果]宫颈癌中EGFR和PKB的阳性表达率均高于对照组,差异均有统计学意义(P<0.05)。EGFR和PKB在宫颈鳞癌中的表达与年龄无关,而与分化程度和临床病理分期(TNM)有关。分化程度低、TNM分期高的患者中EGFR和PKB阳性表达率高于分化程度高、TNM分期低(P<0.05)。EGFR和PKB在宫颈鳞癌组织中的表达呈正相关(r=0.647,P<0.05)。[结论]EGFR和PKB在宫颈鳞癌组织中表达增加,EGFR和PKB表达程度均与分化程度和TNM分期有关。

[Objective] To investigate the expression and significance of EGFR and PKB in cervical cancer. [Methods] Sixty patients with cervical cancer treated in our hospital from January2014 to January 2016 were included in the study,20 samples of normal cervical tissues were used as control group. The expression of EGFR and PKB in cervical cancer and normal cervical tissue was detected with immunohistochemical technique. [Results] The positive expression rates of EGFR and PKB in cervical cancer were higher than those in control group（P0.05）. The expression of EGFR and PKB were correlated with differentiation degree and clinical stages. The expressions of EGFR and PKB in cervical cancer were positively correlated with each other（r=0.647, P〈0.05）. [Conclusion] The expressions of EGFR and PKB are significantly increased in cervical cancer.They are correlated with the degree of differentiation and TNM stage of cervical cancer.