中药药代动力学研究的思与行

Consideration and Exploration on Pharmacokinetic Study of Traditional Chinese Medicine

随着当今中药现代化的发展需求,中药研究不仅在体外寻找其化学物质基础,而且应深入探讨其在体内的处置过程,定量评价中药各化学成分间的相互作用。因此,中药药代动力学研究显得尤为迫切。中药及其复方的药代动力学研究,对系统地阐明和揭示中药作用的物质基础及作用机制,阐明其配伍或组方的原理,科学地指导临床合理用药,促进中医药的现代化具有重要的意义。本文结合研究实例,对中药药代动力学研究的目的和意义,特殊性和难点及常用研究方法等科学问题进行分析与总结,希望对学者们有所帮助,共同推动中药药代动力学研究的发展。

With the development of traditional Chinese medicine（TCM） modernization, the study of TCM is not only limited to clarify the chemical material basis in vitro, but also to further study the fate of active components contained in TCM in vivo as well as the interaction and effect among them. It is to say that the pharmacokinetic（PK） study of TCM is needed. The results of PK study of TCM are useful for investigating its mechanism of action, reasonable use of TCM in clinic and modernization of TCM. In this paper, some scientific issues, including the purpose and significance of PK study of TCM, its particularity, difficulty and commonly used research methods, were analyzed and summarized combining with research examples. The authors hoped that it would be helpful for the scholars and promote the development of PK study of TCM.