超顺磁性氧化铁纳米颗粒在药物靶向递送中的研究进展

Research progress on superparamagnetic iron oxide nanoparticles for targeted drug delivery

超顺磁性氧化铁（SPIO）是一种新型的生物医学纳米材料，具有表面效应、小尺寸效应和宏观量子隧道效应，而较好的生物相容性及超顺磁性使其广泛用于疾病的靶向治疗。相比于其他纳米药物载体，超顺磁性氧化铁纳米颗粒（SPIONs）因其内在属性如固有磁性、良好的安全性及制备和表面修饰方法的可用性等在纳米药物领域中显示出巨大潜力，为其多样的生物医学应用铺平了道路。但研究人员对其不可预知的毒性、改变细胞信号转导和基因表达等方面仍有顾虑。对SPIONs在药物靶向递送中的研究进展作一综述。

Superparamagnetic iron oxide （SPIO） is a novel biomedical nanomaterial with surface effect, small size effect and macroscopic quantum tunneling effect. It has good biocompatibility and superparamagnetism which makes it widely used in targeted therapies. Compared to other nanodrug carriers, superparamagnetic iron oxide nanoparticles （SPIONs） have great potentials in nanodrug filed due to their properties such as intrinsic magnetic, good safety and the availability of surface modifications, etc. These properties provide the basis for their diverse applications in biomedical field. However, researchers are still concerned about the unpredictable toxicity and the changes in cell signal transduction and gene expression of SPIONs. In this paper, the research progress of SPIONs for drug targeting delivery was summarized.