相转移催化合成桂氮酮的动力学

Kinetic Studies on Phase-Transfer Catalytic Synthesis of Azone

动力学研究表明,以三乙基苄基氯化铵作为固-液相转移催化剂,在甲苯液中有粉状氢氧化钾存在下,己内酰胺的N-正十二烷基化生成桂氮酮为准一级反应,表观速度常数k_(80)=3.39×10^(-3)min^(-1)、k_(100)=4.65×10^(-3)min^(-1)。实验显示,反应温度为80℃及100℃时,反应可于4.5 h及3.5 h完成,转化率分别为74%及67%,实际产率为71%及64%;反应的选择性良好,副反应较少。本文还报道了水分对反应的影响。用动力学方法研究合成反应过程,对指导合成工艺具有普遍意义。

Kinetic studies indicated that in toluene and in presence of powdered KOH, N-dodecylation of caprolactam to form azone using triethyl benzyl ammonium chloride as solid-liquid phase transfer catalyst is a reaction of pseudo first order, The apparent rate constants are k′_(80)=3.39×10^(-3)min^(-1)and k′_(100)=4.65×10^(-3)min^(-1). Experiments also revealed that the reaction selectivity is good and by products are relatively rare; when the reaction temperatures are 100℃ and 80℃, the reactions can be accomplished in 3.5 h and 4.5 h with conversion ratios of 67% and 74% respectively (actual yield 64% and 71%). The influence of water on the reaction was also discussed. Studies of synthetic reaction processes by chemical kinetics would be of general significance in directing manufacturing technology.