糖尿病患者发生尿路感染时血清钙与中性粒细胞比例的变化分析

Analysis of serum calcium and percentage of neutrophils in diabetic patients with urinary tract infection

目的分析尿路感染患者血清钙浓度与血液中性粒细胞比例(NEU)的相关性。方法收集2016年1月至7月在江苏南京市高淳区人民医院治疗的继发尿路感染患者的资料,从中筛选出符合研究要求的病例121份,其中非糖尿病患者57例,糖尿病患者64例,对两组患者的血清钙检测结果与血液中NEU进行统计学分析。结果入院时糖尿病组患者血清钙明显低于、NEU明显高于非糖尿病组和正常体检组[Ca^(2+)(mmol/L):2.28±0.17比2.32±0.31、2.35±0.12;NEU(%):64.28±7.14比61.67±7.22、58.69±6.20,均P>0.05];尿路感染时糖尿病组和非糖尿病血清钙明显低于各组入院时[Ca^(2+)(mmol/L):2.07±0.15比2.28±0.17、2.16±0.25比2.32±0.31,均P<0.05],NEU明显高于各组入院时[NEU(%):78.59±10.51比64.28±7.14、74.15±11.97比61.67±7.22],且以糖尿病组变化更显著(均P<0.05);治愈出院时糖尿病组和非糖尿病血清Ca^(2+)和NEU均恢复到各组入院时水平[Ca^(2+)(mmol/L):2.21±0.11比2.28±0.17,2.28±0.26比2.32±0.31;NEU(%):65.53±7.54比64.28±7.14,62.65±6.77比61.67±7.22;均P>0.05],但糖尿病组治愈时血清Ca^(2+)和NEU与正常体检组比较,差异仍有统计学意义。糖尿病患者并发尿路感染时的血清钙与NEU呈明显的负相关(r=-0.471,P<0.05);而非糖尿病患者发生尿路感染时血清钙与NEU无相关性(r=-0.197,P>0.05)。结论尿路感染时患者血清钙水平显著降低;糖尿病患者并发尿路感染时血清钙降低随感染加重越来越明显。

Objective To analyze the correlation of serum calcium concentration and neutrophils in the blood （NEU） in patients with urinary tract infection. Methods Between January and July 2016, patients for treatment of urinary tract infections in Jiangsu Gaochun District People＇s Hospital were screened. One hundred and twenty-one patients were found to meet the study requirements, with 57 cases in non-diabetic patients,and diabetic patients in 64 cases.The serum calcium test results and NEU of two groups of patients were analyzed. Results Serum calcium was lower and NEU was higher in diabetic group than non-diabetic group at admission [Ca2± （mmoI/L）： 2.28±0.17 vs. 2.32±0.31, 2.35±0.12; NEU （%）： 64.28±7.14 vs. 61.67±7.22, 58.69 ± 6.20, all P 〈 0.05]. Compared with levels at admission, serum calcium was lower, and NEU was higher in diabetic group and non-diabetic group [Ca2＋ （mmol/L）： 2.07±0.15 vs. 2.28±0.17, 2.16±0.25 vs. 2.32±0.31, NEU （%）： 78.59 ± 10.51 vs. 64.28 ± 7.14, 74.15 ± 11.97 vs. 61.67 ± 7.22, all P 〈 0.05], and more dramatic changes appeared in diabetic group （both P 〈 0.05）. When cured and discharged, levels of serum calcium and NEU in diabetic group and non-diabetic group returned to the levels of admission [Ca2＋ （mmol/L）： 2.21 ± 0.11 vs. 2.28 ± 0. 17, 2.28±0.26 vs. 2.32±0.31; NEU （%）： 65.53±7.54 vs. 64.28±7.14, 62.65±6.77 vs. 61.67±7.22; all P 〉 0.05], but there were significantly statistical differences between diabetic group and medical examination group. In patients with diabetes complicated with urinary tract infection, serum calcium was significantly negatively correlated with the NEU （r = -0.471, P 〈 0.05）; serum calcium and urinary tract infection in patients with diabetes mellitus and NEU was not associated （r = -0.197, P 〉 0.05）. Conclusion Serum calcium level in urinary tract infectious patients was lower; serum calcium in patients with diabetes mellitus complicated with urinary tract infection increase more and more obvious.