化疗前后乳腺癌患者血细胞参数与化疗疗效的关系探讨

Breast cancer before and after chemotherapy in patients with blood cell parameters and the study on the efficacy of chemotherapy

目的探讨化疗前后乳腺癌患者血细胞参数与化疗疗效的关系。方法选择2014年4月至2016年4月在江苏省泗洪县人民医院住院治疗的58例乳腺癌患者,检测并分析其化疗前后血细胞参数的变化,并以同期住院的50例非肿瘤女性患者和50例正常体检女性人群作为对照。结果 58例乳腺癌患者化疗后的嗜酸粒细胞比例(EOS%)显著升高,与化疗前和其他两个对照组比较差异均有统计学意义[(3.54±3.23)%比(1.70±1.49)%、(0.97±0.54)%、(1.54±1.04)%,均P<0.05];化疗后患者的淋巴细胞比例(LYM%)明显升高[(31.96±11.74)%比(26.90±9.86)%,P<0.05],但与正常体检女性人群比较无统计学意义;血小板计数(PLT)在化疗后显著升高,与化疗前和其他两个对照组比较差异均有统计学意义(×10~9/L:300.68±78.40比254.44±100.91、212.30±54.34、231.52±45.81,均P<0.05);其他参数在化疗前后变化不大,两组比较差异均无统计学意义(均P>0.05)。结论 LYM%、EOS%和PLT升高是乳腺癌患者化疗后的有效评价指标。

Objective To investigate the relationship between the parameters of the blood cells and breast cancer patients chemotherapy curative effect. Methods 58 patients with breast cancer between April 2014 and April 2016 hospitalized in Sihong, Jiangsu Province People＇s Hospital were retrospective analyzed. Blood parameters before and after chemotherapy, at the same time in 50 cases of patients without tumor and 50 cases of normal physical examination people were enrolled as control. Results In 58 patients with breast cancer after chemotherapy acidophilic granulocyte ratio （EOS%） increased significantly, compared with chemotherapy before and the other two control group, and the differences were statistically significant [（3.54 ± 3.23）% to （1.70± 1.49）%, （0.97±0.54）%, （1.54± 1.04）%, P 〈 0.05]; after chemotherapy in patients with lymphocyte percentage （LYM%） significantly increased [（31.96 ± 11.74）% to （26.90 ± 9.86）%, P 〈 0.05）, but no statistical significance was found as compared with the normal physical examination population; platelet count （PLT） increased significantly after chemotherapy, compared with before chemotherapy and the other two control group differences were statistically significant （×10^9/L： 300.68±78.40 vs. 254.44± 100.91, 212.30±54.34 and 54.34±45.81, P 〈 0.05）; the other parameters did not change before and after the chemotherapy, and the two groups were not statistically significant （all P 〉 0.05）. Conclusion The increase of LYM%, EOS% and PLT is an effective evaluation index of breast cancer patients after chemotherapy.