200例海洛因依赖者肌钙蛋白I和C-反应蛋白结果分析

Analysis of TnI and CRP in serum of 200 heroin addicts

目的观察海洛因依赖患者血清肌钙蛋白I(TnI)与C-反应蛋白(CRP)水平的变化,探讨海洛因与人体心肌损害的关系。方法选择乌鲁木齐市第四人民医院2015年1月至2017年1月在门诊治疗的200例海洛因依赖者为研究组,选择2016年10月至2017年6月223例在本院进行健康体检的健康人群作为健康体检对照组;采用酶联免疫吸附法(ELISA)检测两组血清TnI水平,采用速率透射比浊法检测两组血清CRP水平。结果海洛因依赖组血清TnI与CRP均较健康体检对照组升高[TnI(μg/L):0.51±0.26比0.15±0.06,CRP(mg/L):18.1±3.9比6.15±2.57],差异均有统计学意义(均P<0.05)。结论血清TnI与CRP水平的变化在海洛因依赖的发生发展中起重要作用。海洛因可造成人体心肌损害,有关部门应加强对青少年的身心健康教育,使之远离毒品。

Objective To observe the changes of serum cardiac troponin I （TnI） and C-reactive protein （CRP） levels in heroin addicts, and to explore the relationship between heroin addiction and myocardial injury. Methods Two hundred cases of serum samples were collected from heroin addicts outpatients who were admitted to Urumqi City Fourth People＇s Hospital from January 2015 to January 2017, while 223 cases of healthy people were enrolled as health examination control group who were receiving health examination in this hospital from October 2016 to June 2017. Serum levels of TnI were detected by enzyme-linked immunosorbent assay （ELISA）, and CRP were detected by rate transmission turbidimetry. Results The levels of serum TnI and CRP in heroin addicts were higher than those in health examination control group [TnI （μg/L）： 0.51 ± 0.26 vs. 0.15 ± 0.06, CRP （rag/L）： 18.1 ± 3.9 vs. 6.15 ± 2.57]. The differences were statistically significant （P 〈 0.05）. Conclusions The changes of serum TnI and CRP levels play important roles in the development and progression of heroin dependence. Heroin can cause myocardial damage. Therefore the departments concerned should strengthen the psychological health education for adolescents to keep them away from drugs.